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Literature summary extracted from

  • Grubmeyer, C.T.; Gross, J.W.; Rajavel, M.
    Energy coupling through molecular discrimination: nicotinate phosphoribosyltransferase (1999), Methods Enzymol., 308, 28-48.
    View publication on PubMed

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
6.3.4.21 45530
-
 predicted from DNA sequence Salmonella enterica subsp. enterica serovar Typhimurium

Organism

EC Number Organism UniProt Comment Textmining
6.3.4.21 Mycobacterium tuberculosis P9WJW5
-
-
6.3.4.21 Mycobacterium tuberculosis H37Rv P9WJW5
-
-
6.3.4.21 Saccharomyces cerevisiae
-
-
-
6.3.4.21 Saccharomyces cerevisiae P39683
-
-
6.3.4.21 Salmonella enterica subsp. enterica serovar Typhimurium P22253
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.3.4.21 nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O
-
 Mycobacterium tuberculosis beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate
-
 ?
6.3.4.21 nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O
-
 Mycobacterium tuberculosis H37Rv beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate
-
 ?

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
6.3.4.21 additional information
-
 thermostability of the enzyme is increased by ATP and 5-phospho-alpha-D-ribose 1-diphosphate Saccharomyces cerevisiae
6.3.4.21 additional information
-
 thermostability of the enzyme is increased by ATP and 5-phospho-alpha-D-ribose 1-diphosphate Salmonella enterica subsp. enterica serovar Typhimurium

pH Stability

EC Number pH Stability pH Stability Maximum Comment Organism
6.3.4.21 8.3
-
 native enzyme, unstable Salmonella enterica subsp. enterica serovar Typhimurium

Cofactor

EC Number Cofactor Comment Organism Structure
6.3.4.21 ATP 1640fold increase in the product/substrate ratio Salmonella enterica subsp. enterica serovar Typhimurium