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Literature summary extracted from

  • Pescaglini, M.; Micheli, V.; Simmonds, H.A.; Rocchigiani, M.; Pompucci, G.
    Nicotinic acid phosphoribosyltransferase activity in human erythtocytes: studies using a niw HPLC method (1994), Clin. Chim. Acta, 229, 15-25.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.3.4.21 nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O Homo sapiens lack of the de novo pathway for NAD+ synthesis from tryptophan, utilizes both nicotinic acid and nicotinamide as NAD+ precursors beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate
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 ?

Organism

EC Number Organism UniProt Comment Textmining
6.3.4.21 Homo sapiens
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-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
6.3.4.21 heparinised blood lysates Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.3.4.21 erythrocyte
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 Homo sapiens
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Storage Stability

EC Number Storage Stability Organism
6.3.4.21 -70ºC, no significantly decreased activity for up to 3 years, no significantly decreased after 8 years Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.3.4.21 nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O in the presence of Mg2+ and inorganic phosphate Homo sapiens beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate
-
 ?
6.3.4.21 nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O lack of the de novo pathway for NAD+ synthesis from tryptophan, utilizes both nicotinic acid and nicotinamide as NAD+ precursors Homo sapiens beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate
-
 ?