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Literature summary extracted from

  • Imsande, J.
    A cross-linked control system. I. Properties of a triphosphate-dependent nicotinic acid mononucleotide pyrophosphorylase from Bacillus subtilis (1964), Biochim. Biophys. Acta, 85, 255-264.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
6.3.4.21 tripolyphosphate activation, can replace ATP Bacillus subtilis

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.3.4.21 3-acetylpyridine
-
Bacillus subtilis
6.3.4.21 3-Pyridylcarbinol weak inhibitor Bacillus subtilis
6.3.4.21 3-Pyridylcarboxaldehyde
-
Bacillus subtilis
6.3.4.21 5-Fluoronicotinic acid
-
Bacillus subtilis
6.3.4.21 KCN
-
Bacillus subtilis
6.3.4.21 Methyl 3-pyridylcarbinol weak inhibitor Bacillus subtilis
6.3.4.21 additional information no inhibition by nicotinamide; no inhibition by quinolinic acid, AMP, GMP Bacillus subtilis
6.3.4.21 NAD+ not Bacillus subtilis
6.3.4.21 NADP+ not Bacillus subtilis
6.3.4.21 nicotinate mononucleotide not Bacillus subtilis
6.3.4.21 nucleoside diphosphates e.g. ADP or GDP Bacillus subtilis
6.3.4.21 Urea competitive to nicotinate mononucleotide Bacillus subtilis

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
6.3.4.21 0.0008 0.0015 nicotinate
-
Bacillus subtilis
6.3.4.21 0.06 0.1 5-phospho-alpha-D-ribose 1-diphosphate
-
Bacillus subtilis
6.3.4.21 0.34
-
GTP
-
Bacillus subtilis
6.3.4.21 0.35
-
ATP
-
Bacillus subtilis

Organism

EC Number Organism UniProt Comment Textmining
6.3.4.21 Bacillus subtilis
-
SB19
-
6.3.4.21 Bacillus subtilis SB19
-
SB19
-

Purification (Commentary)

EC Number Purification (Comment) Organism
6.3.4.21 partial, extraction, ammonium sulfate fractionation and chromatography on DEAE-cellulose, 60fold purified Bacillus subtilis

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.3.4.21 additional information one mol ATP is cleaved per mol product formed Bacillus subtilis ?
-
?
6.3.4.21 additional information one mol ATP is cleaved per mol product formed Bacillus subtilis SB19 ?
-
?
6.3.4.21 nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O favoured reaction Bacillus subtilis beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate
-
r
6.3.4.21 nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O favoured reaction Bacillus subtilis SB19 beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate
-
r
6.3.4.21 nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + GTP + H2O
-
Bacillus subtilis beta-nicotinate D-ribonucleotide + diphosphate + GDP + phosphate
-
?
6.3.4.21 nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + GTP + H2O
-
Bacillus subtilis SB19 beta-nicotinate D-ribonucleotide + diphosphate + GDP + phosphate
-
?

Synonyms

EC Number Synonyms Comment Organism
6.3.4.21 nicotinic acid mononucleotide pyrophosphorylase
-
Bacillus subtilis

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
6.3.4.21 37
-
assay at Bacillus subtilis

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
6.3.4.21 8.5
-
-
Bacillus subtilis

pH Range

EC Number pH Minimum pH Maximum Comment Organism
6.3.4.21 6.5 9
-
Bacillus subtilis

Cofactor

EC Number Cofactor Comment Organism Structure
6.3.4.21 ATP 1 mol ATP is hydrolyzed to ADP plus phosphate per mol product formed Bacillus subtilis
6.3.4.21 CTP activation, about 70% as effective as ATP Bacillus subtilis
6.3.4.21 GTP activation, equally effective as ATP Bacillus subtilis
6.3.4.21 ITP activation, about 90% as effective as ATP Bacillus subtilis
6.3.4.21 TTP activation, about 30% as effective as ATP Bacillus subtilis
6.3.4.21 UTP activation, about 50% as effective as ATP Bacillus subtilis