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Literature summary extracted from

  • Hayakawa, T.; Shibata, K.; Iwai, K.
    Nicotinate phosphoribosyltransferase from hog liver: regulatory effect of ATP at a physiological concentrations of 5-phosphoribosyl-1-pyrophosphte (1984), Agric. Biol. Chem., 48, 455-460.
No PubMed abstract available

General Stability

EC Number General Stability Organism
6.3.4.21 dialysis against 50 mM Tris-HCl buffer at pH 7.3 in the absence of potassium phosphate, significant loss of activity Rattus norvegicus
6.3.4.21 dialysis against 50 mM Tris-HCl buffer at pH 7.3 in the absence of potassium phosphate, significant loss of activity Sus scrofa

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
6.3.4.21 0.013
-
 5-phospho-alpha-D-ribose 1-diphosphate reduced to 0.002 mM in the presence of ATP Rattus norvegicus
6.3.4.21 0.013
-
 5-phospho-alpha-D-ribose 1-diphosphate reduced to 0.002 mM in the presence of ATP Sus scrofa
6.3.4.21 0.22
-
 nicotinate reduced to 0.053 mM in the presence of ATP Rattus norvegicus
6.3.4.21 0.22
-
 nicotinate reduced to 0.053 mM in the presence of ATP Sus scrofa

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
6.3.4.21 phosphate markedly stimulates even in the absence of ATP Rattus norvegicus
6.3.4.21 phosphate markedly stimulates even in the absence of ATP Sus scrofa

Organism

EC Number Organism UniProt Comment Textmining
6.3.4.21 Rattus norvegicus
-
-
-
6.3.4.21 Sus scrofa
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.3.4.21 liver
-
 Rattus norvegicus
-
6.3.4.21 liver
-
 Sus scrofa
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.3.4.21 nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O
-
 Rattus norvegicus beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate
-
 ?
6.3.4.21 nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O
-
 Sus scrofa beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
6.3.4.21 NPRTase
-
-

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
6.3.4.21 37
-
 assay at Rattus norvegicus
6.3.4.21 37
-
 assay at Sus scrofa

Cofactor

EC Number Cofactor Comment Organism Structure
6.3.4.21 ATP activation Rattus norvegicus
6.3.4.21 ATP activation Sus scrofa
6.3.4.21 ATP requirement in the absence of phosphate Sus scrofa