Literature summary extracted from

Elmgren, A.; Mollicone, R.; Costache, M.; Boerjeson, C.; Oriol, R.; Harrington, J.; Larson, G.
Significance of individual point mutations, T202C and C314T in the human Lewis �FTA3' gene for expression of Lewis antigens by human alpha�1,3/1,4'-fucosyltransferase, Fuc-TIII (1997), J. Biol. Chem., 272, 21994-21998.

Localization

EC Number	Localization	Comment	Organism	GeneOntology No.	Textmining
2.4.1.65	membrane	-	Homo sapiens	16020	-

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
2.4.1.65	GDP-L-fucose + 1,3-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R	Homo sapiens	the enzyme may catalyze alpha1-3 and alpha-1,4 glycosidic linkages involved in the expression of VIM-2, Lewis A, Lewis B, sialyl Lewis X and Lewis X/SSEA-1 antigens. May be involved in blood group Lewis determination. Lewis-positive individuals have an active enzyme while Lewis-negative individuals have an inactive enzyme	GDP + 1,3-beta-D-galactosyl-(alpha-(1,4)-L-fucosyl)-N-acetyl-D-glucosaminyl-R	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.4.1.65	Homo sapiens	P21217	-	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2.4.1.65	GDP-L-fucose + 1,3-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R	the enzyme may catalyze alpha1-3 and alpha-1,4 glycosidic linkages involved in the expression of VIM-2, Lewis A, Lewis B, sialyl Lewis X and Lewis X/SSEA-1 antigens. May be involved in blood group Lewis determination. Lewis-positive individuals have an active enzyme while Lewis-negative individuals have an inactive enzyme	Homo sapiens	GDP + 1,3-beta-D-galactosyl-(alpha-(1,4)-L-fucosyl)-N-acetyl-D-glucosaminyl-R	-	?

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Release 2023.1 (January 2023)