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Literature summary extracted from

  • Kuhn, J.; Götting, C.; Schnolzer, M.; Kempf, T.; Brinkmann, T.; Kleesiek, K.
    First isolation of human UDP-D-xylose:proteoglycan core protein beta-D-xylosyltransferase secreted from cultured JAR choriocarcinoma cells (2001), J. Biol. Chem., 276, 4940-4947.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.4.2.26 extracellular in cell culture supernatant Homo sapiens
-
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.4.2.26 additional information
-
 enzyme activity is also detected in a peak of MW 500000 Homo sapiens
2.4.2.26 120000
-
 gel filtration, amino acid sequence determination Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.2.26 UDP-alpha-D-xylose + [protein]-L-serine Homo sapiens enzyme initiates the biosynthesis of glycosaminoglycan lateral chains in proteoglycans by transfer of xylose from UDP-xylose to specific serine residues of the core protein UDP + [protein]-3-O-(beta-D-xylosyl)-L-serine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.2.26 Homo sapiens
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.4.2.26 glycoprotein N-glycosylated Homo sapiens

Purification (Commentary)

EC Number Purification (Comment) Organism
2.4.2.26 from cell culture supernatant Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.2.26 choriocarcinoma cell
-
 Homo sapiens
-
2.4.2.26 JAR cell choriocarcinoma cell line Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.4.2.26 0.0285
-
 purified enzyme Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.26 UDP-alpha-D-xylose + [protein]-L-serine transfers a beta-D-xylosyl residue from UDP-D-xylose to the serine hydroxyl group of an acceptor protein substrate Homo sapiens UDP + [protein]-3-O-(beta-D-xylosyl)-L-serine
-
 ?
2.4.2.26 UDP-alpha-D-xylose + [protein]-L-serine enzyme initiates the biosynthesis of glycosaminoglycan lateral chains in proteoglycans by transfer of xylose from UDP-xylose to specific serine residues of the core protein Homo sapiens UDP + [protein]-3-O-(beta-D-xylosyl)-L-serine
-
 ?

Subunits

EC Number Subunits Comment Organism
2.4.2.26 monomer 1 * 120000, SDS-PAGE Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
2.4.2.26 XT
-
 Homo sapiens