Literature summary extracted from

  • Anwar, R.A.; Vlaovic, M.
    Effect of phosphoenolpyruvate analogs on the activity of enoylpyruvate transferase and the effect of UDP-N-acetylglucosamine on the reactivity of the active site SH group (1980), Biochim. Biophys. Acta, 616, 389-394.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.5.1.7 3-Bromopyruvate irreversible, inhibitory effect is increased by UDP-GlcNAc Enterobacter cloacae
2.5.1.7 fosfomycin irreversible, active site SH-group is involved Enterobacter cloacae
2.5.1.7 additional information no inhibition by pyruvate and fluoropyruvate Enterobacter cloacae
2.5.1.7 phosphoenol-2-ketovalerate
-
Enterobacter cloacae

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.5.1.7 phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine Enterobacter cloacae enzyme catalyzes the first committed step in the biosynthesis of bacterial cell wall peptidoglycan phosphate + UDP-N-acetyl-3-(1-carboxyvinyl)-D-glucosamine
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.7 Enterobacter cloacae
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.7 additional information no activity with (Z)-phosphoenol-2-oxobutyrate, phosphoenol-3-bromopyruvate and phosphoenol-3-phenylpyruvate Enterobacter cloacae ?
-
?
2.5.1.7 phosphoenol-2-oxobutyrate + UDP-N-acetyl-D-glucosamine
-
Enterobacter cloacae phosphate + UDP-N-acetylglucosaminyl-enol-2-oxobutyrate
-
?
2.5.1.7 phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine
-
Enterobacter cloacae phosphate + UDP-N-acetyl-3-(1-carboxyvinyl)-D-glucosamine i.e. UDP-N-acetyl-D-glucosamine-enolpyruvate ?
2.5.1.7 phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine enzyme catalyzes the first committed step in the biosynthesis of bacterial cell wall peptidoglycan Enterobacter cloacae phosphate + UDP-N-acetyl-3-(1-carboxyvinyl)-D-glucosamine
-
?

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.5.1.7 1.7
-
phosphoenol-2-ketovalerate
-
Enterobacter cloacae