Literature summary extracted from

Kerr, D.; Flavin, M.
Inhibition of cystathionine gamma-synthase by S-adenosylmethionine: A control mechanism for methionine synthesis in Neurospora (1969), Biochim. Biophys. Acta, 177, 177-179.

General Stability

EC Number	General Stability	Organism
2.5.1.48	EDTA and dithiothreitol stabilize	Neurospora crassa

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
2.5.1.48	S-adenosyl-L-homocysteine	-	Neurospora crassa
2.5.1.48	S-adenosyl-L-methionine	0.003 mM, 34% inhibition , 0.1 mM, 96% inhibition, physiological inhibitor	Neurospora crassa

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
2.5.1.48	O-succinyl-L-homoserine + L-cysteine	Neurospora crassa	methionine biosynthesis	L-cystathionine + succinate	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.5.1.48	Neurospora crassa	-	-	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2.5.1.48	O-succinyl-L-homoserine + L-cysteine	-	Neurospora crassa	L-cystathionine + succinate	-	?
2.5.1.48	O-succinyl-L-homoserine + L-cysteine	methionine biosynthesis	Neurospora crassa	L-cystathionine + succinate	-	?

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Release 2023.1 (January 2023)