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Literature summary extracted from

  • Duewel, H.S.; Woodard, R.W.
    A metal bridge between two enzyme families. 3-Deoxy-D-manno-octulosonate-8-phosphate synthase from Aquifex aeolicus requires a divalent metal for activity (2000), J. Biol. Chem., 275, 22824-22831.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.5.1.55 1,10-phenanthroline
-
 Aquifex aeolicus
2.5.1.55 Cd2+ 10 mM Aquifex aeolicus
2.5.1.55 Cu2+ 10 mM Aquifex aeolicus
2.5.1.55 EDTA reactivation by divalent metal ions Aquifex aeolicus
2.5.1.55 Mn2+ 10 mM Aquifex aeolicus
2.5.1.55 Zn2+ 10 mM Aquifex aeolicus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.5.1.55 Cd2+ maximal activation below 0.1 mM Aquifex aeolicus
2.5.1.55 Cu2+ maximal activation below 0.1 mM Aquifex aeolicus
2.5.1.55 Fe2+ contains 0.2-0.3 equivalents of iron per enzyme subunit. FeSO4 stimulates Aquifex aeolicus
2.5.1.55 Zn2+ enzyme contains approximately 0.4 equivalents of zinc per enzyme subunit. Maximal activation below 0.1 mM Zn2+ Aquifex aeolicus

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.55 Aquifex aeolicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.5.1.55 recombinant enzyme Aquifex aeolicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.55 phosphoenolpyruvate + D-arabinose 5-phosphate
-
 Aquifex aeolicus 2-dehydro-3-deoxy-D-octonate 8-phosphate + phosphate
-
 ?
2.5.1.55 phosphoenolpyruvate + erythrose 4-phosphate
-
 Aquifex aeolicus 3-deoxy-D-ribo-heptulosonate 7-phosphate
-
 ?