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Literature summary extracted from

  • Birck, M.R.; Woodard, R.W.
    Aquifex aeolicus 3-Deoxy-D-manno-2-octulosonic acid 8-phosphate synthase: A new class of KDO 8-P synthase? (2001), J. Mol. Evol., 52, 205-214.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.5.1.55 expression in Escherichia coli Chlamydia psittaci

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.5.1.55 1,10-phenanthroline
-
 Aquifex aeolicus
2.5.1.55 1,10-phenanthroline
-
 Chlamydia psittaci
2.5.1.55 1,10-phenanthroline
-
 Helicobacter pylori
2.5.1.55 dipicolinic acid
-
 Chlamydia psittaci
2.5.1.55 EDTA
-
 Aquifex aeolicus
2.5.1.55 EDTA
-
 Chlamydia psittaci
2.5.1.55 EDTA
-
 Helicobacter pylori

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.5.1.55 phosphoenolpyruvate + D-arabinose-5-phosphate + H2O Aquifex aeolicus the enzyme catalyzes the first commited step in the production of 2-dehydro-3-deoxy-D-octonate, an integral part of the inner core region of the lipopolysaccharide layer in Gram-negative bacteria 2-dehydro-3-deoxy-D-octonate 8-phosphate + phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.55 Actinobacillus pleuropneumoniae O68662
-
-
2.5.1.55 Aggregatibacter actinomycetemcomitans
-
-
-
2.5.1.55 Aquifex aeolicus
-
-
-
2.5.1.55 Aquifex aeolicus O66496
-
-
2.5.1.55 Arabidopsis thaliana
-
-
-
2.5.1.55 Bordetella bronchiseptica
-
-
-
2.5.1.55 Bordetella pertussis
-
-
-
2.5.1.55 Campylobacter jejuni
-
-
-
2.5.1.55 Caulobacter vibrioides
-
-
-
2.5.1.55 Chlamydia pneumoniae Q9Z7I4
-
-
2.5.1.55 Chlamydia psittaci Q46225
-
-
2.5.1.55 Chlamydia trachomatis P0CD74
-
-
2.5.1.55 Chlorobaculum tepidum
-
-
-
2.5.1.55 Escherichia coli P0A715
-
-
2.5.1.55 Haemophilus influenzae P45251
-
-
2.5.1.55 Helicobacter pylori
-
 26695
-
2.5.1.55 Helicobacter pylori Q9ZN55 J99
-
2.5.1.55 Klebsiella pneumoniae
-
-
-
2.5.1.55 Mannheimia haemolytica P95514
-
-
2.5.1.55 Neisseria gonorrhoeae Q9XB02
-
-
2.5.1.55 Neisseria meningitidis Q9XAZ3
-
-
2.5.1.55 Pasteurella multocida
-
-
-
2.5.1.55 Pisum sativum
-
-
-
2.5.1.55 Porphyromonas gingivalis
-
-
-
2.5.1.55 Pseudomonas aeruginosa Q9ZFK4
-
-
2.5.1.55 Rickettsia prowazekii Q9ZE84
-
-
2.5.1.55 Salmonella enterica subsp. enterica serovar Typhi
-
-
-
2.5.1.55 Shewanella putrefaciens
-
-
-
2.5.1.55 Vibrio cholerae serotype O1
-
-
-
2.5.1.55 Yersinia pestis
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.55 phosphoenolpyruvate + D-arabinose 5-phosphate
-
 Pisum sativum 2-dehydro-3-deoxy-D-octonate 8-phosphate + phosphate
-
 ?
2.5.1.55 phosphoenolpyruvate + D-arabinose 5-phosphate
-
 Arabidopsis thaliana 2-dehydro-3-deoxy-D-octonate 8-phosphate + phosphate
-
 ?
2.5.1.55 phosphoenolpyruvate + D-arabinose 5-phosphate
-
 Bordetella bronchiseptica 2-dehydro-3-deoxy-D-octonate 8-phosphate + phosphate
-
 ?
2.5.1.55 phosphoenolpyruvate + D-arabinose 5-phosphate
-
 Klebsiella pneumoniae 2-dehydro-3-deoxy-D-octonate 8-phosphate + phosphate
-
 ?
2.5.1.55 phosphoenolpyruvate + D-arabinose 5-phosphate
-
 Helicobacter pylori 2-dehydro-3-deoxy-D-octonate 8-phosphate + phosphate
-
 ?
2.5.1.55 phosphoenolpyruvate + D-arabinose 5-phosphate
-
 Yersinia pestis 2-dehydro-3-deoxy-D-octonate 8-phosphate + phosphate
-
 ?
2.5.1.55 phosphoenolpyruvate + D-arabinose 5-phosphate
-
 Caulobacter vibrioides 2-dehydro-3-deoxy-D-octonate 8-phosphate + phosphate
-
 ?
2.5.1.55 phosphoenolpyruvate + D-arabinose 5-phosphate
-
 Salmonella enterica subsp. enterica serovar Typhi 2-dehydro-3-deoxy-D-octonate 8-phosphate + phosphate
-
 ?
2.5.1.55 phosphoenolpyruvate + D-arabinose 5-phosphate
-
 Porphyromonas gingivalis 2-dehydro-3-deoxy-D-octonate 8-phosphate + phosphate
-
 ?
2.5.1.55 phosphoenolpyruvate + D-arabinose 5-phosphate
-
 Vibrio cholerae serotype O1 2-dehydro-3-deoxy-D-octonate 8-phosphate + phosphate
-
 ?
2.5.1.55 phosphoenolpyruvate + D-arabinose 5-phosphate
-
 Bordetella pertussis 2-dehydro-3-deoxy-D-octonate 8-phosphate + phosphate
-
 ?
2.5.1.55 phosphoenolpyruvate + D-arabinose 5-phosphate
-
 Aggregatibacter actinomycetemcomitans 2-dehydro-3-deoxy-D-octonate 8-phosphate + phosphate
-
 ?
2.5.1.55 phosphoenolpyruvate + D-arabinose 5-phosphate
-
 Chlorobaculum tepidum 2-dehydro-3-deoxy-D-octonate 8-phosphate + phosphate
-
 ?
2.5.1.55 phosphoenolpyruvate + D-arabinose 5-phosphate
-
 Aquifex aeolicus 2-dehydro-3-deoxy-D-octonate 8-phosphate + phosphate
-
 ?
2.5.1.55 phosphoenolpyruvate + D-arabinose 5-phosphate
-
 Campylobacter jejuni 2-dehydro-3-deoxy-D-octonate 8-phosphate + phosphate
-
 ?
2.5.1.55 phosphoenolpyruvate + D-arabinose 5-phosphate
-
 Shewanella putrefaciens 2-dehydro-3-deoxy-D-octonate 8-phosphate + phosphate
-
 ?
2.5.1.55 phosphoenolpyruvate + D-arabinose 5-phosphate
-
 Pasteurella multocida 2-dehydro-3-deoxy-D-octonate 8-phosphate + phosphate
-
 ?
2.5.1.55 phosphoenolpyruvate + D-arabinose 5-phosphate
-
 Actinobacillus pleuropneumoniae 2-dehydro-3-deoxy-D-octonate 8-phosphate + phosphate
-
 ?
2.5.1.55 phosphoenolpyruvate + D-arabinose 5-phosphate
-
 Chlamydia pneumoniae 2-dehydro-3-deoxy-D-octonate 8-phosphate + phosphate
-
 ?
2.5.1.55 phosphoenolpyruvate + D-arabinose 5-phosphate
-
 Chlamydia psittaci 2-dehydro-3-deoxy-D-octonate 8-phosphate + phosphate
-
 ?
2.5.1.55 phosphoenolpyruvate + D-arabinose 5-phosphate
-
 Chlamydia trachomatis 2-dehydro-3-deoxy-D-octonate 8-phosphate + phosphate
-
 ?
2.5.1.55 phosphoenolpyruvate + D-arabinose 5-phosphate
-
 Escherichia coli 2-dehydro-3-deoxy-D-octonate 8-phosphate + phosphate
-
 ?
2.5.1.55 phosphoenolpyruvate + D-arabinose 5-phosphate
-
 Haemophilus influenzae 2-dehydro-3-deoxy-D-octonate 8-phosphate + phosphate
-
 ?
2.5.1.55 phosphoenolpyruvate + D-arabinose 5-phosphate
-
 Neisseria gonorrhoeae 2-dehydro-3-deoxy-D-octonate 8-phosphate + phosphate
-
 ?
2.5.1.55 phosphoenolpyruvate + D-arabinose 5-phosphate
-
 Neisseria meningitidis 2-dehydro-3-deoxy-D-octonate 8-phosphate + phosphate
-
 ?
2.5.1.55 phosphoenolpyruvate + D-arabinose 5-phosphate
-
 Mannheimia haemolytica 2-dehydro-3-deoxy-D-octonate 8-phosphate + phosphate
-
 ?
2.5.1.55 phosphoenolpyruvate + D-arabinose 5-phosphate
-
 Pseudomonas aeruginosa 2-dehydro-3-deoxy-D-octonate 8-phosphate + phosphate
-
 ?
2.5.1.55 phosphoenolpyruvate + D-arabinose 5-phosphate
-
 Rickettsia prowazekii 2-dehydro-3-deoxy-D-octonate 8-phosphate + phosphate
-
 ?
2.5.1.55 phosphoenolpyruvate + D-arabinose-5-phosphate + H2O the enzyme catalyzes the first commited step in the production of 2-dehydro-3-deoxy-D-octonate, an integral part of the inner core region of the lipopolysaccharide layer in Gram-negative bacteria Aquifex aeolicus 2-dehydro-3-deoxy-D-octonate 8-phosphate + phosphate
-
 ?

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
2.5.1.55 0.095
-
 phosphoenolpyruvate
-
 Helicobacter pylori
2.5.1.55 0.333
-
 phosphoenolpyruvate
-
 Helicobacter pylori
2.5.1.55 0.333
-
 D-arabinose 5-phosphate
-
 Helicobacter pylori