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Literature summary extracted from

  • Blacklow, R.S.; Warren, L.
    Biosynthesis of sialic acids by Neisseria meningitidis (1962), J. Biol. Chem., 237, 3520-3526.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.5.1.56 glutathione required for maximal activity Neisseria meningitidis

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.5.1.56 EDTA 10 mM, complete inhibition Neisseria meningitidis

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.5.1.56 0.042
-
phosphoenolpyruvate
-
Neisseria meningitidis
2.5.1.56 6.25
-
N-acetyl-D-mannosamine
-
Neisseria meningitidis

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.5.1.56 Co2+ at optimal concentration 50% of the activation with Mg2+ Neisseria meningitidis
2.5.1.56 Mg2+ at optimal concentration 50% of the activation with Mg2+ Neisseria meningitidis
2.5.1.56 Mn2+ divalent metal required Neisseria meningitidis
2.5.1.56 Mn2+ Mn2+ is most effective, optimal concentration: 5 mM Neisseria meningitidis

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.56 Neisseria meningitidis
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.5.1.56
-
Neisseria meningitidis

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.5.1.56 0.06
-
-
Neisseria meningitidis

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.56 N-acetyl-D-mannosamine + phosphoenolpyruvate + H2O specific for Neisseria meningitidis N-acetylneuraminate + phosphate
-
ir
2.5.1.56 N-acetyl-D-mannosamine + phosphoenolpyruvate + H2O the reaction strongly favors the formation of N-acetylneuraminic acid and appears to be irreversible Neisseria meningitidis N-acetylneuraminate + phosphate
-
ir

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.5.1.56 8.3
-
in Tris buffer Neisseria meningitidis

pH Range

EC Number pH Minimum pH Maximum Comment Organism
2.5.1.56 6.5 10 pH 6.5: about 40% of maximal activity, pH 10.0: about 60% of maximal activity Neisseria meningitidis