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Literature summary extracted from

  • Nagpurkar, A.; Hunt, D.; Mookerjea, S.
    Specific stimulation of alpha 2-6 sialyltransferase activity by a novel cytosolic factor from rat colon (1996), Int. J. Biochem. Cell Biol., 28, 1337-1348.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.4.3.1 natural factor from rat colon stimulation is decreased by CTP, no activation at 0.75 mM CTP Rattus norvegicus
2.4.3.1 natural factor from rat colon partially purified Rattus norvegicus
2.4.3.1 natural factor from rat colon specific, 4fold stimulation by decreasing the Km value for the substrates and increasing Vmax, present in the cytosol, temperature dependent, protease sensitive, independent of metal ions or detergent, unaffceted by monosaccharides Rattus norvegicus
2.4.3.1 natural factor from rat colon may also be present in rat brain and kidney Rattus norvegicus
2.4.3.1 Triton X-100
-
Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.3.1 CTP also decreases the stimulation by the natural cytosolic rat colon factor Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.4.3.1 0.14
-
CMP-N-acetylneuraminate with stimulation by the natural cytosolic crat colon factor Rattus norvegicus
2.4.3.1 0.23
-
asialo-alpha1-acid glycoprotein with stimulation by the natural cytosolic crat colon factor Rattus norvegicus
2.4.3.1 0.24
-
CMP-N-acetylneuraminate without stimulation by the natural cytosolic crat colon factor Rattus norvegicus
2.4.3.1 0.53
-
asialo-alpha1-acid glycoprotein without stimulation by the natural cytosolic crat colon factor Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.4.3.1 Golgi apparatus
-
Rattus norvegicus 5794
-
2.4.3.1 membrane
-
Rattus norvegicus 16020
-
2.4.3.1 microsome
-
Rattus norvegicus
-
-

Organism

EC Number Organism UniProt Comment Textmining
2.4.3.1 Rattus norvegicus
-
Sprague-Dawley
-
2.4.3.1 Rattus norvegicus
-
purified enzyme
-
2.4.3.1 Rattus norvegicus Sprague-Dawley
-
Sprague-Dawley
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.4.3.1 partial Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.3.1 jejunum
-
Rattus norvegicus
-
2.4.3.1 liver
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.4.3.1 additional information
-
activity of stimulated and unstimulated enzyme with different substrates Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.3.1 CMP-N-acetylneuraminate + asialo-orosomucoid i.e. asialo-alpha1 acid glycoprotein Rattus norvegicus CMP + orosomucoid
-
?
2.4.3.1 CMP-N-acetylneuraminate + asialo-orosomucoid i.e. asialo-alpha1 acid glycoprotein Rattus norvegicus Sprague-Dawley CMP + orosomucoid
-
?
2.4.3.1 CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine
-
Rattus norvegicus CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine
-
?
2.4.3.1 CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine
-
Rattus norvegicus Sprague-Dawley CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine
-
?
2.4.3.1 CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R acceptor substrate specificity Rattus norvegicus CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
-
?
2.4.3.1 CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R sialic acid is linked to C-6 of the galactose residue Rattus norvegicus CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
-
?
2.4.3.1 CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R synthetic disaccharides Rattus norvegicus CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
-
?
2.4.3.1 CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R acceptor substrate specificity Rattus norvegicus Sprague-Dawley CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
-
?
2.4.3.1 CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R sialic acid is linked to C-6 of the galactose residue Rattus norvegicus Sprague-Dawley CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
-
?
2.4.3.1 CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R synthetic disaccharides Rattus norvegicus Sprague-Dawley CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
-
?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.4.3.1 37
-
assay at Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.4.3.1 6.8
-
assay at Rattus norvegicus