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Literature summary extracted from

  • Fujita, A.
    Thiaminase (1954), Adv. Enzymol. Relat. Subj. Biochem., 15, 389-421.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.5.1.2 aniline activated by 1 mM Equisetum arvense
2.5.1.2 aniline activated by 1 mM Pteridium aquilinum
2.5.1.2 aniline activated by 1 mM Polystichum tsus-simense
2.5.1.2 aniline activated by 1 mM Polystichum aculeatum
2.5.1.2 aniline activated by 1 mM Polystichum fortunei
2.5.1.2 aniline activated by 1 mM Osmunda japonica
2.5.1.2 aniline activated by 1 mM Athyrium nipponicum
2.5.1.2 aniline activated by 1 mM Struthiopteris nipponica
2.5.1.2 aniline activated by 1 mM Dryopteris erythrosora
2.5.1.2 aniline not activated by 1 mM Lycopodium clavatum
2.5.1.2 aniline not activated by 1 mM Dicranopteris linearis
2.5.1.2 aromatic amines increased activity, aniline is the most potent activator, primary amines not directly attached to the benzene ring have no effect Carassius auratus
2.5.1.2 aromatic amines increased activity, aniline is the most potent activator, primary amines not directly attached to the benzene ring have no effect Pteridium aquilinum
2.5.1.2 aromatic amines increased activity, aniline is the most potent activator, primary amines not directly attached to the benzene ring have no effect Paenibacillus thiaminolyticus
2.5.1.2 aromatic amines increased activity, aniline is the most potent activator, primary amines not directly attached to the benzene ring have no effect Meretrix meretrix
2.5.1.2 aromatic amines increased activity, aniline is the most potent activator, primary amines not directly attached to the benzene ring have no effect Celosia crista
2.5.1.2 heterocyclic amines pyridine, 2-amino-pyridine, 3-amino-pyridine increase activity Carassius auratus
2.5.1.2 heterocyclic amines pyridine, 2-amino-pyridine, 3-amino-pyridine increase activity Pteridium aquilinum
2.5.1.2 heterocyclic amines pyridine, 2-amino-pyridine, 3-amino-pyridine increase activity Paenibacillus thiaminolyticus
2.5.1.2 heterocyclic amines pyridine, 2-amino-pyridine, 3-amino-pyridine increase activity Meretrix meretrix
2.5.1.2 heterocyclic amines pyridine, 2-amino-pyridine, 3-amino-pyridine increase activity Celosia crista
2.5.1.2 heterocyclic amines nicotinic acid and quinolone increase activity Pteridium aquilinum
2.5.1.2 heterocyclic amines nicotinic acid and quinolone increase activity Paenibacillus thiaminolyticus
2.5.1.2 heterocyclic amines most 4-aminopyrimidines are inhibitory Carassius auratus
2.5.1.2 heterocyclic amines most 4-aminopyrimidines are inhibitory Meretrix meretrix
2.5.1.2 heterocyclic amines most 4-aminopyrimidines increase activity Paenibacillus thiaminolyticus
2.5.1.2 additional information aliphatic amines and taurine have no effect Carassius auratus
2.5.1.2 additional information aliphatic amines and taurine have no effect Pteridium aquilinum
2.5.1.2 additional information aliphatic amines and taurine have no effect Paenibacillus thiaminolyticus
2.5.1.2 additional information aliphatic amines and taurine have no effect Meretrix meretrix
2.5.1.2 additional information aliphatic amines and taurine have no effect Celosia crista
2.5.1.2 additional information L-phenylalanine, L-tyrosine, L-tryptophan and gamma-aceto-gammachloropropyl acetate have no effect Carassius auratus
2.5.1.2 additional information L-phenylalanine, L-tyrosine, L-tryptophan and gamma-aceto-gammachloropropyl acetate have no effect Paenibacillus thiaminolyticus
2.5.1.2 additional information L-phenylalanine, L-tyrosine, L-tryptophan and gamma-aceto-gammachloropropyl acetate have no effect Meretrix meretrix
2.5.1.2 sulfhydryl compounds increase activity, more markedly in bacteria Carassius auratus
2.5.1.2 sulfhydryl compounds increase activity, more markedly in bacteria Paenibacillus thiaminolyticus
2.5.1.2 sulfhydryl compounds increase activity, more markedly in bacteria Meretrix meretrix

Application

EC Number Application Comment Organism
2.5.1.2 medicine
-
 Equisetum arvense
2.5.1.2 medicine ferns that have thiaminase produce thiamine deficiency in rat, cattle and horse Pteridium aquilinum
2.5.1.2 medicine bacteria can infect organisms and produce thiaminase disease Paenibacillus thiaminolyticus
2.5.1.2 medicine bacteria can infect organisms and produce thiaminase disease Aneurinibacillus aneurinilyticus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.5.1.2 4-aminopyrimidines mostly inhibitory Carassius auratus
2.5.1.2 4-aminopyrimidines mostly inhibitory Meretrix meretrix
2.5.1.2 aromatic amines inhibited by or without effect Aneurinibacillus aneurinilyticus
2.5.1.2 Cu2+ different inhibitory effects at 1 mM Aneurinibacillus aneurinilyticus
2.5.1.2 Cu2+ different inhibitory effects at 1 mM Carassius auratus
2.5.1.2 Cu2+ different inhibitory effects at 1 mM Celosia crista
2.5.1.2 Cu2+ different inhibitory effects at 1 mM Dicranopteris sp.
2.5.1.2 Cu2+ different inhibitory effects at 1 mM Meretrix meretrix
2.5.1.2 Cu2+ no inhibition Paenibacillus thiaminolyticus
2.5.1.2 Cu2+ different inhibitory effects at 1 mM Pteridium aquilinum
2.5.1.2 Fe2+ different inhibitory effects at 1 mM Aneurinibacillus aneurinilyticus
2.5.1.2 Fe2+ different inhibitory effects at 1 mM Carassius auratus
2.5.1.2 Fe2+ different inhibitory effects at 1 mM Celosia crista
2.5.1.2 Fe2+ different inhibitory effects at 1 mM Dicranopteris sp.
2.5.1.2 Fe2+ different inhibitory effects at 1 mM Meretrix meretrix
2.5.1.2 Fe2+ no inhibition Paenibacillus thiaminolyticus
2.5.1.2 Fe2+ different inhibitory effects at 1 mM Pteridium aquilinum
2.5.1.2 heterocyclic amines
-
 Aneurinibacillus aneurinilyticus
2.5.1.2 Mn2+ different inhibitory effects at 1 mM Aneurinibacillus aneurinilyticus
2.5.1.2 Mn2+ different inhibitory effects at 1 mM Carassius auratus
2.5.1.2 Mn2+ different inhibitory effects at 1 mM Celosia crista
2.5.1.2 Mn2+ different inhibitory effects at 1 mM Dicranopteris sp.
2.5.1.2 Mn2+ different inhibitory effects at 1 mM Meretrix meretrix
2.5.1.2 Mn2+ different inhibitory effects at 1 mM Paenibacillus thiaminolyticus
2.5.1.2 Mn2+ different inhibitory effects at 1 mM Pteridium aquilinum

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.2 Acanthogobius flavimanus
-
 goby
-
2.5.1.2 Anadara inflata
-
-
-
2.5.1.2 Aneurinibacillus aneurinilyticus
-
 BKA
-
2.5.1.2 Aneurinibacillus aneurinilyticus BKA
-
 BKA
-
2.5.1.2 Anguilla japonica
-
 eel
-
2.5.1.2 Athyrium nipponicum
-
-
-
2.5.1.2 Auxis hira
-
-
-
2.5.1.2 Carassius auratus
-
 crucian carp
-
2.5.1.2 Celosia crista
-
 cockscomb
-
2.5.1.2 Charybdis 6-dentata
-
-
-
2.5.1.2 Circe scripta
-
-
-
2.5.1.2 Clava kochi
-
-
-
2.5.1.2 Corbicula leana
-
-
-
2.5.1.2 Cristaria plicata
-
 fresh-water mussel
-
2.5.1.2 Cyprinus carpio
-
 carp
-
2.5.1.2 Dicranopteris linearis
-
-
-
2.5.1.2 Dicranopteris sp.
-
-
-
2.5.1.2 Dryopteris erythrosora
-
-
-
2.5.1.2 Dryopteris lacera
-
-
-
2.5.1.2 Eleotris oxycephala
-
-
-
2.5.1.2 Equisetum arvense
-
 horsetail
-
2.5.1.2 Eviota abax
-
-
-
2.5.1.2 Gnathopogon mayedae
-
-
-
2.5.1.2 Haliotis gigantea
-
-
-
2.5.1.2 Haliotis japonica
-
-
-
2.5.1.2 Hypomesus olidus
-
-
-
2.5.1.2 Ischikauia steenackeri
-
-
-
2.5.1.2 Leptochilus ellipticus
-
 var. Typican
-
2.5.1.2 Leucopsarion petersii
-
-
-
2.5.1.2 Lycopodium clavatum
-
-
-
2.5.1.2 Mactra quadrangularis
-
-
-
2.5.1.2 Mactra sulcataria
-
-
-
2.5.1.2 Meretrix meretrix
-
 clam
-
2.5.1.2 Misgurnus anguillicaudatus
-
 loach
-
2.5.1.2 Mugil cephalus
-
 grey mullet
-
2.5.1.2 no activity in Astroconger myriaster
-
-
-
2.5.1.2 no activity in Cambaroides japonicus
-
-
-
2.5.1.2 no activity in Camposcia retusa
-
-
-
2.5.1.2 no activity in Metapenaeopsis acclivis
-
-
-
2.5.1.2 no activity in Plecoglossus altivelis
-
-
-
2.5.1.2 no activity in Squilla oratoria
-
-
-
2.5.1.2 Odontobutis obscura
-
-
-
2.5.1.2 Osmunda japonica
-
 osmund royal
-
2.5.1.2 Ostrea laperousei
-
 oyster
-
2.5.1.2 Paenibacillus thiaminolyticus
-
 BMM strain
-
2.5.1.2 Paenibacillus thiaminolyticus
-
 equal to Paenibacillus thiaminolyticum, CKL
-
2.5.1.2 Paenibacillus thiaminolyticus BMM
-
 BMM strain
-
2.5.1.2 Panulirus japonicus
-
 spiny lobster
-
2.5.1.2 Paphia philippinarum
-
-
-
2.5.1.2 Polystichum aculeatum
-
 var. Japonicum
-
2.5.1.2 Polystichum falcatum
-
-
-
2.5.1.2 Polystichum fortunei
-
-
-
2.5.1.2 Polystichum tsus-simense
-
-
-
2.5.1.2 Portunus trituberculatus
-
 crab
-
2.5.1.2 Pteridium aquilinum
-
 var. Japonicum, bracken fern
-
2.5.1.2 Rhinogobius similis
-
-
-
2.5.1.2 Silurus asotus
-
 catfish
-
2.5.1.2 Solen gouldi
-
 razor shell
-
2.5.1.2 Struthiopteris nipponica
-
-
-
2.5.1.2 Thiara libertina
-
-
-
2.5.1.2 Turbo cornutus
-
-
-
2.5.1.2 Umbonium costatum
-
-
-
2.5.1.2 Viviparus malleatus
-
 mud snail
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.5.1.2 brain
-
 Cyprinus carpio
-
2.5.1.2 eye ball Cyprinus carpio
-
2.5.1.2 eye ball Auxis hira
-
2.5.1.2 flower less activity than in leaves Celosia crista
-
2.5.1.2 gastrointestinal tract
-
 Cyprinus carpio
-
2.5.1.2 gastrointestinal tract
-
 Anguilla japonica
-
2.5.1.2 gastrointestinal tract
-
 Eleotris oxycephala
-
2.5.1.2 gastrointestinal tract
-
 Acanthogobius flavimanus
-
2.5.1.2 gastrointestinal tract
-
 Ischikauia steenackeri
-
2.5.1.2 gill
-
 Carassius auratus
-
2.5.1.2 gill
-
 Cyprinus carpio
-
2.5.1.2 gill
-
 Anguilla japonica
-
2.5.1.2 gill
-
 Mugil cephalus
-
2.5.1.2 gill
-
 Eleotris oxycephala
-
2.5.1.2 gill
-
 Auxis hira
-
2.5.1.2 gill
-
 Acanthogobius flavimanus
-
2.5.1.2 gill
-
 Odontobutis obscura
-
2.5.1.2 head
-
 Anguilla japonica
-
2.5.1.2 head
-
 Misgurnus anguillicaudatus
-
2.5.1.2 heart
-
 Cyprinus carpio
-
2.5.1.2 heart
-
 Acanthogobius flavimanus
-
2.5.1.2 intestine
-
 Carassius auratus
-
2.5.1.2 intestine
-
 Silurus asotus
-
2.5.1.2 intestine
-
 Auxis hira
-
2.5.1.2 kidney
-
 Silurus asotus
-
2.5.1.2 kidney highest activity Carassius auratus
-
2.5.1.2 kidney highest activity Cyprinus carpio
-
2.5.1.2 kidney highest activity Mugil cephalus
-
2.5.1.2 leaf
-
 Celosia crista
-
2.5.1.2 liver
-
 Carassius auratus
-
2.5.1.2 liver
-
 Cyprinus carpio
-
2.5.1.2 liver
-
 Mugil cephalus
-
2.5.1.2 liver
-
 Silurus asotus
-
2.5.1.2 liver
-
 Eleotris oxycephala
-
2.5.1.2 liver
-
 Acanthogobius flavimanus
-
2.5.1.2 liver
-
 Ischikauia steenackeri
-
2.5.1.2 liver
-
 Odontobutis obscura
-
2.5.1.2 liver
-
 Portunus trituberculatus
-
2.5.1.2 liver
-
 Panulirus japonicus
-
2.5.1.2 liver
-
 Charybdis 6-dentata
-
2.5.1.2 liver no activity Anguilla japonica
-
2.5.1.2 liver scarcely found Eviota abax
-
2.5.1.2 muscle
-
 Cyprinus carpio
-
2.5.1.2 muscle
-
 Misgurnus anguillicaudatus
-
2.5.1.2 muscle
-
 Auxis hira
-
2.5.1.2 muscle
-
 Acanthogobius flavimanus
-
2.5.1.2 muscle no activity Anguilla japonica
-
2.5.1.2 muscle scarcely found Carassius auratus
-
2.5.1.2 muscle scarcely found Turbo cornutus
-
2.5.1.2 muscle scarcely found Haliotis gigantea
-
2.5.1.2 muscle scarcely found Haliotis japonica
-
2.5.1.2 muscle scarcely found Portunus trituberculatus
-
2.5.1.2 muscle scarcely found Panulirus japonicus
-
2.5.1.2 ovary
-
 Carassius auratus
-
2.5.1.2 ovary
-
 Cyprinus carpio
-
2.5.1.2 ovary
-
 Misgurnus anguillicaudatus
-
2.5.1.2 pancreas scarcely found Cyprinus carpio
-
2.5.1.2 skin
-
 Cyprinus carpio
-
2.5.1.2 spleen
-
 Cyprinus carpio
-
2.5.1.2 spleen
-
 Mugil cephalus
-
2.5.1.2 spleen
-
 Silurus asotus
-
2.5.1.2 spleen highest activity found Eleotris oxycephala
-
2.5.1.2 stomach
-
 Silurus asotus
-
2.5.1.2 testis scarcely found Cyprinus carpio
-
2.5.1.2 viscus high activity Turbo cornutus
-
2.5.1.2 viscus high activity Haliotis gigantea
-
2.5.1.2 viscus high activity Corbicula leana
-
2.5.1.2 whole body
-
 Equisetum arvense
-
2.5.1.2 whole body
-
 Pteridium aquilinum
-
2.5.1.2 whole body
-
 Lycopodium clavatum
-
2.5.1.2 whole body
-
 Gnathopogon mayedae
-
2.5.1.2 whole body
-
 Meretrix meretrix
-
2.5.1.2 whole body
-
 Paphia philippinarum
-
2.5.1.2 whole body
-
 Solen gouldi
-
2.5.1.2 whole body
-
 Umbonium costatum
-
2.5.1.2 whole body
-
 Cristaria plicata
-
2.5.1.2 whole body
-
 Corbicula leana
-
2.5.1.2 whole body
-
 Circe scripta
-
2.5.1.2 whole body
-
 Viviparus malleatus
-
2.5.1.2 whole body
-
 Clava kochi
-
2.5.1.2 whole body
-
 Mactra quadrangularis
-
2.5.1.2 whole body
-
 Polystichum tsus-simense
-
2.5.1.2 whole body
-
 Polystichum aculeatum
-
2.5.1.2 whole body
-
 Polystichum fortunei
-
2.5.1.2 whole body
-
 Osmunda japonica
-
2.5.1.2 whole body
-
 Athyrium nipponicum
-
2.5.1.2 whole body
-
 Polystichum falcatum
-
2.5.1.2 whole body
-
 Struthiopteris nipponica
-
2.5.1.2 whole body
-
 Dryopteris lacera
-
2.5.1.2 whole body
-
 Leptochilus ellipticus
-
2.5.1.2 whole body
-
 Dicranopteris linearis
-
2.5.1.2 whole body
-
 Dryopteris erythrosora
-
2.5.1.2 whole body very low activity Rhinogobius similis
-
2.5.1.2 whole body very low activity Hypomesus olidus
-
2.5.1.2 whole body very low activity Leucopsarion petersii
-
2.5.1.2 whole body very low activity Ostrea laperousei
-
2.5.1.2 whole body very low activity Thiara libertina
-
2.5.1.2 whole body very low activity Mactra sulcataria
-
2.5.1.2 whole body very low activity Anadara inflata
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.2 thiamine + aniline
-
 Cyprinus carpio 5-(anilinomethyl)-2-methylpyrimidin-4-amine + 4-methyl-5-(2-hydroxyethyl)-thiazole
-
 ?
2.5.1.2 thiamine + aniline
-
 Paenibacillus thiaminolyticus 5-(anilinomethyl)-2-methylpyrimidin-4-amine + 4-methyl-5-(2-hydroxyethyl)-thiazole
-
 ?
2.5.1.2 thiamine + aniline
-
 Aneurinibacillus aneurinilyticus 5-(anilinomethyl)-2-methylpyrimidin-4-amine + 4-methyl-5-(2-hydroxyethyl)-thiazole
-
 ?
2.5.1.2 thiamine + aniline
-
 Aneurinibacillus aneurinilyticus BKA 5-(anilinomethyl)-2-methylpyrimidin-4-amine + 4-methyl-5-(2-hydroxyethyl)-thiazole
-
 ?
2.5.1.2 thiamine + aniline
-
 Paenibacillus thiaminolyticus BMM 5-(anilinomethyl)-2-methylpyrimidin-4-amine + 4-methyl-5-(2-hydroxyethyl)-thiazole
-
 ?

Temperature Range [°C]

EC Number Temperature Minimum [°C] Temperature Maximum [°C] Comment Organism
2.5.1.2 50 60 maximal activity Pteridium aquilinum
2.5.1.2 90
-
 inactivation after 15 min Meretrix meretrix
2.5.1.2 90
-
 inactivation after 10 min Carassius auratus
2.5.1.2 100
-
 inactivation after 15 min Pteridium aquilinum
2.5.1.2 100
-
 inactivation after 15 min Dicranopteris sp.
2.5.1.2 100
-
 inactivation after 15 min Celosia crista
2.5.1.2 100
-
 inactivation after 10 min Aneurinibacillus aneurinilyticus
2.5.1.2 100
-
 inactivation after 10 min Corbicula leana
2.5.1.2 100
-
 inactivation after 20 min Paenibacillus thiaminolyticus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.5.1.2 5
-
-
 Paenibacillus thiaminolyticus
2.5.1.2 5
-
-
 Meretrix meretrix
2.5.1.2 5.5
-
-
 Corbicula leana
2.5.1.2 5.5
-
-
 Celosia crista
2.5.1.2 6
-
-
 Carassius auratus
2.5.1.2 6
-
-
 Pteridium aquilinum
2.5.1.2 6
-
-
 Dicranopteris sp.
2.5.1.2 7.5
-
-
 Paenibacillus thiaminolyticus
2.5.1.2 8
-
-
 Aneurinibacillus aneurinilyticus