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Literature summary extracted from

  • Carlson, D.M.; McGuire, E.J.; Jourdian, G.W.; Roseman, S.
    The sialic acids. XVI. Isolation of a mucin sialyltransferase from sheep submaxillary gland (1973), J. Biol. Chem., 248, 5763-5773.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.3.3 Ca2+ CaCl2, at 0.004 M: 30% inhibition, at 0.016 M: 60% inhibition Ovis aries
2.4.3.3 additional information not inhibited by EDTA; not inhibited by Mg2+; not inhibited by native ovine submaxillary mucin Ovis aries

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.4.3.3 0.57
-
CMP-N-acetylneuraminate 37°C Ovis aries
2.4.3.3 1.9
-
submaxillary asialo-mucin ovine, calculated in terms of N-acetylgalactosamine acceptor sites, 37°C Ovis aries

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.4.3.3 additional information no divalent metal cation requirement Ovis aries

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.3.3 CMP-N-acetylneuraminate + glycano-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein Ovis aries last step in the synthesis of ovine submaxillary mucin, catalyzes the chain-terminating process in oligosaccharide synthesis of glycoproteins, may well be involved in the process of secretion CMP + glycano-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.4.3.3 Ovis aries
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.4.3.3 partial, 44fold Ovis aries

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.3.3 submaxillary gland
-
Ovis aries
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.4.3.3 0.00435
-
-
Ovis aries

Storage Stability

EC Number Storage Stability Organism
2.4.3.3 frozen, crude preparation, at least 2 months, stable Ovis aries

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.3.3 CMP-N-acetylneuraminate + asialo-fetuin
-
Ovis aries CMP + fetuin
-
?
2.4.3.3 CMP-N-acetylneuraminate + asialo-milk glycopeptide
-
Ovis aries CMP + milk glycopeptide
-
?
2.4.3.3 CMP-N-acetylneuraminate + erythrocyte hemagglutination inhibitor
-
Ovis aries ?
-
?
2.4.3.3 CMP-N-acetylneuraminate + glycano-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein last step in the synthesis of ovine submaxillary mucin, catalyzes the chain-terminating process in oligosaccharide synthesis of glycoproteins, may well be involved in the process of secretion Ovis aries CMP + glycano-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein
-
?
2.4.3.3 CMP-N-acetylneuraminate + native fetuin
-
Ovis aries ?
-
?
2.4.3.3 CMP-N-acetylneuraminate + R-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein erythrocyte hemagglutination inhibitor, milk glycopeptide Ovis aries CMP + R-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein
-
ir
2.4.3.3 CMP-N-acetylneuraminate + R-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein CMP-N-glycolylneuraminate can replace CMP-N-acetylneuraminate Ovis aries CMP + R-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein
-
ir
2.4.3.3 CMP-N-acetylneuraminate + R-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein asialo-fetuin Ovis aries CMP + R-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein
-
ir
2.4.3.3 CMP-N-acetylneuraminate + R-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein bovine submaxillary asialo-mucin Ovis aries CMP + R-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein
-
ir
2.4.3.3 CMP-N-acetylneuraminate + R-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein specific for alpha-N-acetylgalactosamine attached through alpha-glycosidic linkage to threonine or serine in polypeptide chain Ovis aries CMP + R-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein
-
ir
2.4.3.3 CMP-N-acetylneuraminate + R-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein porcine submaxillary asialo-mucin Ovis aries CMP + R-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein
-
ir
2.4.3.3 CMP-N-acetylneuraminate + R-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein native submaxillary mucin, less effective than asialo-mucin Ovis aries CMP + R-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein
-
ir
2.4.3.3 CMP-N-acetylneuraminate + R-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein native fetuin Ovis aries CMP + R-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein
-
ir
2.4.3.3 CMP-N-acetylneuraminate + R-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein ovine submaxillary asialo-mucin, with simple O-linked GalNAcalpha-Thr/Ser Ovis aries CMP + R-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein
-
ir
2.4.3.3 CMP-N-acetylneuraminate + submaxillary asialo-mucin bovine submaxillary asialo-mucin Ovis aries CMP + submaxillary mucin linkage formed is NeuAc(2-6)GalNAcalpha(1-)O-Thr/Ser ir
2.4.3.3 CMP-N-acetylneuraminate + submaxillary asialo-mucin porcine submaxillary asialo-mucin Ovis aries CMP + submaxillary mucin linkage formed is NeuAc(2-6)GalNAcalpha(1-)O-Thr/Ser ir
2.4.3.3 CMP-N-acetylneuraminate + submaxillary asialo-mucin ovine submaxillary asialo-mucin is the most effective acceptor Ovis aries CMP + submaxillary mucin linkage formed is NeuAc(2-6)GalNAcalpha(1-)O-Thr/Ser ir
2.4.3.3 CMP-N-glycolylneuraminate + R-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein
-
Ovis aries CMP + R-(2,6-alpha-N-glycolylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein
-
?
2.4.3.3 additional information no acceptors: asialo-collacalia mucoid, asialo-proteose peptone, asialo-prothrombin, asialo-thyroglobulin, asialo-transferrin, asialo-chondromucoprotein fractions from cartilage, human blood group substance A or B, various sugars Ovis aries ?
-
?
2.4.3.3 additional information no acceptor: lactose Ovis aries ?
-
?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.4.3.3 37
-
assay at Ovis aries

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.4.3.3 6 6.1 with cacodylate-acetate buffer Ovis aries