EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.6.1.49 | Al3+ | strong inhibition | Alcaligenes faecalis | |
2.6.1.49 | Co2+ | weak inhibition | Alcaligenes faecalis | |
2.6.1.49 | Cu2+ | strong inhibition | Alcaligenes faecalis | |
2.6.1.49 | Fe2+ | strong inhibition | Alcaligenes faecalis | |
2.6.1.49 | Ni2+ | inhibition of ADT and GDT, not PDT | Alcaligenes faecalis | |
2.6.1.49 | Zn2+ | weak inhibition | Alcaligenes faecalis |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.6.1.49 | Alcaligenes faecalis | - |
IAM 1015 | - |
2.6.1.49 | Alcaligenes faecalis IAM 1015 | - |
IAM 1015 | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.6.1.49 | 3-(3,4-dihydroxyphenyl)pyruvate + L-aspartate | aspartate-3,4-dihydroxyphenylpyruvate transaminase, ADT | Alcaligenes faecalis | 3,4-dihydroxy-L-phenylalanine + oxaloacetate | i.e. L-dopa | ? | |
2.6.1.49 | 3-(3,4-dihydroxyphenyl)pyruvate + L-aspartate | aspartate-3,4-dihydroxyphenylpyruvate transaminase, ADT | Alcaligenes faecalis IAM 1015 | 3,4-dihydroxy-L-phenylalanine + oxaloacetate | i.e. L-dopa | ? | |
2.6.1.49 | 3-(3,4-dihydroxyphenyl)pyruvate + L-glutamate | glutamate-3,4-dihydroxyphenylpyruvate transaminase, GDT | Alcaligenes faecalis | 3-(3,4-dihydroxyphenyl)-L-alanine + 2-oxoglutarate | i.e. L-dopa | ? | |
2.6.1.49 | 3-(3,4-dihydroxyphenyl)pyruvate + L-glutamate | glutamate-3,4-dihydroxyphenylpyruvate transaminase, GDT | Alcaligenes faecalis IAM 1015 | 3-(3,4-dihydroxyphenyl)-L-alanine + 2-oxoglutarate | i.e. L-dopa | ? | |
2.6.1.49 | 3-(3,4-dihydroxyphenyl)pyruvate + L-phenylalanine | phenylalanine-3,4-dihydroxyphenylpyruvate transaminase, PDT | Alcaligenes faecalis | 3,4-dihydroxy-L-phenylalanine + 3-phenylpyruvate | i.e. L-dopa | ? | |
2.6.1.49 | 3-(3,4-dihydroxyphenyl)pyruvate + L-phenylalanine | phenylalanine-3,4-dihydroxyphenylpyruvate transaminase, PDT | Alcaligenes faecalis IAM 1015 | 3,4-dihydroxy-L-phenylalanine + 3-phenylpyruvate | i.e. L-dopa | ? |
EC Number | Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|---|
2.6.1.49 | 60 | - |
15 min, complete loss of activity, enzyme GDT | Alcaligenes faecalis |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
2.6.1.49 | 7.4 | - |
GDT | Alcaligenes faecalis |
2.6.1.49 | 9 | 10 | ADT | Alcaligenes faecalis |
2.6.1.49 | 9.5 | - |
PDT | Alcaligenes faecalis |
EC Number | pH Stability | pH Stability Maximum | Comment | Organism |
---|---|---|---|---|
2.6.1.49 | 8 | - |
45°C, 30 min, enzyme GDT stable | Alcaligenes faecalis |
2.6.1.49 | 8.5 | 9 | 45°C, 30 min, enzyme PDT stable | Alcaligenes faecalis |