EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.6.1.57 | 4-hydroxyphenylpyruvate | substrate inhibition | Candida maltosa | |
2.6.1.57 | Indole pyruvate | substrate inhibition | Candida maltosa | |
2.6.1.57 | phenylpyruvate | substrate inhibition | Candida maltosa | |
2.6.1.57 | prephenate | substrate inhibition | Candida maltosa |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.6.1.57 | additional information | - |
additional information | Km values of AAT I and II are very similar for a variety of substrates, Km values for AAT II are higher | Candida maltosa | |
2.6.1.57 | 0.001 | - |
pyridoxal 5'-phosphate | pH 8.6, 37°C, AAT I | Candida maltosa | |
2.6.1.57 | 0.05 | - |
4-hydroxyphenylpyruvate | pH 8.6, 37°C, AAT I | Candida maltosa | |
2.6.1.57 | 0.06 | - |
Indolepyruvate | pH 8.6, 37°C, AAT I | Candida maltosa | |
2.6.1.57 | 0.08 | - |
phenylpyruvate | pH 8.6, 37°C, AAT I | Candida maltosa | |
2.6.1.57 | 0.08 | - |
prephenate | pH 8.6, 37°C, AAT I | Candida maltosa | |
2.6.1.57 | 0.4 | - |
L-tyrosine | pH 8.6, 37°C, AAT I | Candida maltosa | |
2.6.1.57 | 0.44 | - |
L-phenylalanine | pH 8.6, 37°C, AAT I | Candida maltosa | |
2.6.1.57 | 0.45 | - |
L-arogenate | pH 8.6, 37°C, AAT I | Candida maltosa | |
2.6.1.57 | 2.5 | - |
L-tryptophan | pH 8.6, 37°C, AAT I | Candida maltosa | |
2.6.1.57 | 3.3 | - |
oxaloacetate | pH 8.6, 37°C, AAT I | Candida maltosa | |
2.6.1.57 | 4 | - |
L-leucine | pH 8.6, 37°C, AAT I | Candida maltosa | |
2.6.1.57 | 5 | - |
2-oxoglutarate | pH 8.6, 37°C, AAT I | Candida maltosa | |
2.6.1.57 | 5 | - |
L-methionine | pH 8.6, 37°C, AAT I | Candida maltosa | |
2.6.1.57 | 5 | - |
L-histidine | pH 8.6, 37°C, AAT I | Candida maltosa | |
2.6.1.57 | 7 | - |
L-glutamine | pH 8.6, 37°C, AAT I | Candida maltosa |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
2.6.1.57 | 73000 | - |
isoenzyme AAT-I, gel filtration | Candida maltosa |
2.6.1.57 | 85000 | - |
isoenzyme AAT-II, gel filtration | Candida maltosa |
2.6.1.57 | 105000 | - |
isoenzyme AAT-III, gel filtration | Candida maltosa |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.6.1.57 | Candida maltosa | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
2.6.1.57 | DEAE-cellulose, isolation of isoenzymes AAT I, AAT II and AAT III | Candida maltosa |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.6.1.57 | L-arogenate + indolepyruvate | - |
Candida maltosa | L-tryptophan + 3-(1-carboxy-4-hydroxycyclohexa-2,5-dienyl)2-oxopropanoate | - |
? | |
2.6.1.57 | L-glutamine + indole pyruvate | AAT I and II | Candida maltosa | 2-oxoglutamine + L-tryptophan | - |
? | |
2.6.1.57 | L-histidine + indole pyruvate | - |
Candida maltosa | 3-(1H-imidazol-4-yl)-2-oxopropanoate + L-tryptophan | - |
? | |
2.6.1.57 | L-leucine + indole pyruvate | - |
Candida maltosa | 4-methyl-2-oxopentanoate + L-tryptophan | - |
? | |
2.6.1.57 | L-methionine + indole pyruvate | AAT I and II | Candida maltosa | 4-methylsulfanyl-2-oxobutanoate + L-tryptophan | - |
? | |
2.6.1.57 | L-phenylalanine + 2-oxoglutarate | completely inactive with D-isomers of aromatic amino acids | Candida maltosa | phenylpyruvate + L-glutamate | - |
? | |
2.6.1.57 | L-phenylalanine + 2-oxoglutarate | specificities of isoenzymes: AAT I, AAT II, AAT III | Candida maltosa | phenylpyruvate + L-glutamate | - |
? | |
2.6.1.57 | L-tryptophan + 2-oxoglutarate | - |
Candida maltosa | 3-indole-2-oxopropanoate + L-glutamate | - |
? | |
2.6.1.57 | L-tryptophan + indole pyruvate | - |
Candida maltosa | 3-indole-2-oxopropanoate + L-tryptophan | - |
? | |
2.6.1.57 | L-tryptophan + oxaloacetate | - |
Candida maltosa | 3-indole-2-oxopropanoate + L-aspartate | - |
? | |
2.6.1.57 | L-tryptophan + phenylpyruvate | - |
Candida maltosa | 3-indole-2-oxopropanoate + L-phenylalanine | - |
? | |
2.6.1.57 | L-tyrosine + 2-oxoglutarate | - |
Candida maltosa | p-hydroxyphenylpyruvate + L-glutamate | - |
? | |
2.6.1.57 | L-tyrosine + indole pyruvate | - |
Candida maltosa | 4-hydroxyphenylpyruvate + L-tryptophan | - |
? | |
2.6.1.57 | prephenate + L-glutamate | - |
Candida maltosa | 1-carboxy-4-hydroxy-2,5-cyclohexadien-1-alanine + 2-oxoglutarate | - |
? | |
2.6.1.57 | prephenate + L-tryptophan | - |
Candida maltosa | 1-carboxy-4-hydroxy-2,5-cyclohexadien-1-alanine + 3-indole-2-oxopropanoate | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.6.1.57 | AAT I-III | i.e. aromatic aminotransferase I, II and III | Candida maltosa |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
2.6.1.57 | pyridoxal 5'-phosphate | a pyridoxal phosphate protein | Candida maltosa | |
2.6.1.57 | pyridoxal 5'-phosphate | Km: 0.001 mM, isoenzyme AAT I, 0.0005 mM, isoenzyme AAT II, AAT III | Candida maltosa |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.6.1.57 | 0.3 | - |
indolpyruvate | AAT I, substrate inhibition | Candida maltosa | |
2.6.1.57 | 0.3 | - |
4-hydroxyphenylpyruvate | AAT III, substrate inhibition | Candida maltosa | |
2.6.1.57 | 0.3 | - |
indolpyruvate | AAT I and III, substrate inhibition | Candida maltosa | |
2.6.1.57 | 0.4 | - |
prephenate | AAT I, substrate inhibition | Candida maltosa | |
2.6.1.57 | 0.4 | - |
4-hydroxyphenylpyruvate | AAT I, substrate inhibition | Candida maltosa | |
2.6.1.57 | 0.4 | - |
prephenate | AAT I and III, substrate inhibition | Candida maltosa | |
2.6.1.57 | 0.5 | - |
phenylpyruvate | AAT I, substrate inhibition | Candida maltosa | |
2.6.1.57 | 0.5 | - |
phenylpyruvate | AAT III, substrate inhibition | Candida maltosa | |
2.6.1.57 | 1.5 | - |
indolpyruvate | AAT II, substrate inhibition | Candida maltosa | |
2.6.1.57 | 10 | - |
4-hydroxyphenylpyruvate | AAT II, substrate inhibition | Candida maltosa | |
2.6.1.57 | 15 | - |
phenylpyruvate | AAT II, substrate inhibition | Candida maltosa | |
2.6.1.57 | 15 | - |
prephenate | AAT II, substrate inhibition | Candida maltosa |