Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Guidetti, P.; Okuno, E.; Schwarcz, R.
    Characterization of rat brain kynurenine aminotransferases I and II (1997), J. Neurosci. Res., 50, 457-465.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.6.1.7 3-hydroxykynurenine 0.6 mM, 54% inhibition of KAT I, 88% inhibition of KAT II Rattus norvegicus
2.6.1.7 alpha-aminoadipate strong inhibition of KAT II Rattus norvegicus
2.6.1.7 glutamine strong inhibition of KAT I Rattus norvegicus
2.6.1.7 L-phenylalanine strong inhibition of KAT I Rattus norvegicus
2.6.1.7 L-tryptophan strong inhibition of KAT I Rattus norvegicus
2.6.1.7 additional information KAT I is not inhibited by quisqualate Rattus norvegicus
2.6.1.7 quisqualate 0.52 mM, 50% inhibition of KAT II, 2 mM, 80% inhibition Rattus norvegicus
2.6.1.7 S-dichlorovinyl-L-cysteine 2 mM, 90% inhibition of KAT I and KAT II Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.6.1.7 0.024
-
 2-oxoglutarate pH 9.5, 37°C, KAT I Rattus norvegicus
2.6.1.7 0.053
-
 pyruvate pH 9.5, 37°C, KAT I Rattus norvegicus
2.6.1.7 0.717
-
 pyruvate pH 7.0, 37°C, KAT II Rattus norvegicus
2.6.1.7 0.879
-
 2-oxoglutarate pH 7.0, 37°C, KAT II Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
2.6.1.7 Rattus norvegicus
-
 KAT I and KAT II
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.6.1.7 DEAE-Sepharose, ammonium sulfate, Sephadex G-25, partial purification of KAT I and KAT II Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.6.1.7 brain KAT I and KAT II Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.6.1.7 L-kynurenine + 2-oxoglutarate KAT II shows equal activity with 2-oxoglutarate and pyruvate, KAT I shows lower activity with 2-oxoglutarate than with pyruvate, ratio of KAT I to KAT II in normal brain is approx. 1/4 Rattus norvegicus kynurenic acid + L-glutamate + H2O
-
 ?
2.6.1.7 L-kynurenine + pyruvate
-
 Rattus norvegicus kynurenic acid + L-alanine + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.6.1.7 More brain KAT I is identical with glutamine transferase K Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.6.1.7 7 7.5 KAT II Rattus norvegicus
2.6.1.7 9 9.5 KAT I Rattus norvegicus