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Literature summary extracted from

  • Noguchi, T.; Minatogawa, Y.; Okuno, E.; Nakatani, M.; Morimoto, M.; Kido, R.
    Purification and characterization of kynurenine-2-oxoglutarate aminotransferase from the liver, brain and small intestine of rats (1975), Biochem. J., 151, 399-406.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.6.1.7 additional information not inhibited by aspartate, tyrosine, phenylalanine Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.6.1.7 mitochondrion
-
 Rattus norvegicus 5739
-
2.6.1.7 soluble
-
 Rattus norvegicus
-
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.6.1.7 100000
-
 isoenzyme 2, sucrose density gradient centrifugation Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
2.6.1.7 Rattus norvegicus
-
 Donryu
-
2.6.1.7 Rattus norvegicus
-
 isoenzyme 2
-
2.6.1.7 Rattus norvegicus Donryu
-
 Donryu
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.6.1.7 DEAE-cellulose, heat treatment, hydroxyapatite, CM-Sephadex C-25, Sephadex G-100 Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.6.1.7 0.13
-
 isoenzyme 2 Rattus norvegicus
2.6.1.7 7.8
-
-
 Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.6.1.7 L-kynurenine + 2-oxoglutarate isoenzyme 2, no activity with L-tyrosine, L-phenylalanine, L-tryptophan, 5-hydroxy-L-tryptophan and L-aspartate Rattus norvegicus kynurenic acid + L-glutamate + H2O
-
 ?
2.6.1.7 L-kynurenine + 2-oxoglutarate isoenzyme 2, no activity with L-tyrosine, L-phenylalanine, L-tryptophan, 5-hydroxy-L-tryptophan and L-aspartate Rattus norvegicus Donryu kynurenic acid + L-glutamate + H2O
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.6.1.7 37
-
 assay at Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.6.1.7 6 6.5
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
2.6.1.7 pyridoxal 5'-phosphate
-
 Rattus norvegicus