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Literature summary extracted from

  • Mason, M.
    Kynurenine transaminase of rat kidney: a study of coenzyme dissociation (1957), J. Biol. Chem., 227, 61-68.
    View publication on PubMed

General Stability

EC Number General Stability Organism
2.6.1.7 alcohol fractionation inactivates Rattus norvegicus
2.6.1.7 ammonium sulfate fractionation inactivates Rattus norvegicus
2.6.1.7 dialysis against phosphate buffer inactivates, 2-oxoglutarate protects to some extent Rattus norvegicus
2.6.1.7 freeze-thawing inactivates Rattus norvegicus
2.6.1.7 slightly acidic buffer solutions inactivate, pyridoxal phosphate or pyridoxamine phosphate restores activity, 2-oxoglutarate protects Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
2.6.1.7 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.6.1.7 partial purification of kynurenine apotransaminase Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.6.1.7 L-kynurenine + 2-oxoglutarate
-
 Rattus norvegicus kynurenic acid + L-glutamate + H2O
-
 ?
2.6.1.7 L-kynurenine + 2-oxoisohexanoate less effective than 2-oxoglutarate Rattus norvegicus kynurenic acid + 2-aminoisohexanoate + H2O
-
 ?
2.6.1.7 L-kynurenine + oxaloacetate
-
 Rattus norvegicus kynurenic acid + L-aspartate + H2O
-
 ?
2.6.1.7 L-kynurenine + pyruvate less effective than 2-oxoglutarate Rattus norvegicus kynurenic acid + L-alanine + H2O
-
 ?

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
2.6.1.7 37
-
 phosphate buffer, pH 6.3, inactivation within a few min, pyridoxal phosphate restores activity, only slow inactivation at pH 7.4, 2-oxoglutarate protects Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
2.6.1.7 pyridoxal 5'-phosphate
-
 Rattus norvegicus