Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Teng-Leary, E.; Kohlhaw, G.B.
    Mechanism of feedback inhibition by leucine. Binding of leucine to wild-type and feedback-resistant alpha-isopropylmalate synthases and its structural consequences (1973), Biochemistry, 12, 2980-2986.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.3.13 leucine mechanism of feedback inhibition by Leu, binding of Leu to wild-type and feedback-resistant enzyme and its structural consequences Salmonella enterica subsp. enterica serovar Typhimurium

Organism

EC Number Organism UniProt Comment Textmining
2.3.3.13 Salmonella enterica subsp. enterica serovar Typhimurium
-
strain CV-19, and mutant strain CV-241 with a feed-back insensitive enzyme
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.3.13 2-oxo-3-methylbutanoate + acetyl-CoA + H2O
-
Salmonella enterica subsp. enterica serovar Typhimurium 3-hydroxy-4-methyl-3-carboxypentanoate + CoA
-
?

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.3.3.13 0.008
-
leucine pH 6.8, 0.4 mM acetyl-CoA, 0.1 mM 2-oxo-3-methylbutanoate, wild-type enzyme Salmonella enterica subsp. enterica serovar Typhimurium
2.3.3.13 0.022
-
leucine pH 6.8, 0.8 mM acetyl-CoA, 4 mM 2-oxo-3-methylbutanoate, wild-type enzyme Salmonella enterica subsp. enterica serovar Typhimurium
2.3.3.13 3
-
leucine pH 6.8, 0.4 mM acetyl-CoA, 0.1 mM 2-oxo-3-methylbutanoate, feedback-resistent enzyme Salmonella enterica subsp. enterica serovar Typhimurium
2.3.3.13 20
-
leucine pH 6.8, 0.8 mM acetyl-CoA, 4 mM 2-oxo-3-methylbutanoate, feedback-resistent enzyme Salmonella enterica subsp. enterica serovar Typhimurium