EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.3.3.13 | 5',5',5'-trifluoroleucine | reversed by acetyl-CoA | Neurospora crassa | |
2.3.3.13 | Br- | above 0.02 M | Neurospora crassa | |
2.3.3.13 | DL-azaleucine | 10 mM, at pH 6.5 | Neurospora crassa | |
2.3.3.13 | DL-fluoroleucine | at pH 7.5 | Neurospora crassa | |
2.3.3.13 | F- | above 0.02 M | Neurospora crassa | |
2.3.3.13 | L-Phe | 10 mM, at pH 6.5 | Neurospora crassa | |
2.3.3.13 | L-Val | 10 mM, at pH 6.5 | Neurospora crassa | |
2.3.3.13 | leucine | at pH 7.5 | Neurospora crassa | |
2.3.3.13 | Zn2+ | 0.1 mM | Neurospora crassa |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.3.3.13 | 0.01 | - |
2-oxo-3-methylbutanoate | - |
Neurospora crassa | |
2.3.3.13 | 0.0245 | - |
acetyl-CoA | pH 7.5 | Neurospora crassa | |
2.3.3.13 | 0.028 | - |
acetyl-CoA | pH 7.0 | Neurospora crassa | |
2.3.3.13 | 0.035 | - |
acetyl-CoA | pH 6.6 | Neurospora crassa | |
2.3.3.13 | 2.1 | - |
2-oxo-butanoate | - |
Neurospora crassa | |
2.3.3.13 | 5.8 | - |
pyruvate | - |
Neurospora crassa |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
2.3.3.13 | K+ | - |
Neurospora crassa | |
2.3.3.13 | Li+ | stimulates at low concentrations | Neurospora crassa |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.3.3.13 | 2-oxo-3-methylbutanoate + acetyl-CoA + H2O | Neurospora crassa | first enzyme in biosynthesis of L-Leu | ? | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.3.3.13 | Neurospora crassa | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
2.3.3.13 | - |
Neurospora crassa |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
2.3.3.13 | additional information | - |
- |
Neurospora crassa |
EC Number | Storage Stability | Organism |
---|---|---|
2.3.3.13 | -20°C, phosphate leucine buffer, little loss of activity | Neurospora crassa |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.3.3.13 | 2-oxo-3-methylbutanoate + acetyl-CoA + H2O | - |
Neurospora crassa | 3-hydroxy-4-methyl-3-carboxypentanoate + CoA | - |
? | |
2.3.3.13 | 2-oxo-3-methylbutanoate + acetyl-CoA + H2O | first enzyme in biosynthesis of L-Leu | Neurospora crassa | ? | - |
? | |
2.3.3.13 | 2-oxo-butanoate + acetyl-CoA + H2O | - |
Neurospora crassa | 2-ethyl-2-hydroxysuccinic acid + CoA | - |
? | |
2.3.3.13 | pyruvate + acetyl-CoA + H2O | - |
Neurospora crassa | 2-hydroxy-2-methylsuccinic acid + CoA | - |
? |
EC Number | Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|---|
2.3.3.13 | additional information | - |
thermal stability at pH 6.5 increases as a function of Leu concentration. The protection afforded by Leu is greatest at pH 6.5, less at pH 7.5, and is entirely lost at pH 8.3 | Neurospora crassa |
2.3.3.13 | 49 | - |
7 min, 90% loss of activity in absence of Leu, about 50% loss of activity after 15 min in presence of 0.2 mM Leu | Neurospora crassa |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
2.3.3.13 | 7 | 8 | - |
Neurospora crassa |