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Literature summary extracted from

  • Wiegel, J.; Schlegel, H.G.
    alpha-Isopropylmalate synthase from Alcaligenes eutrophus H 16. II. Substrate specificity and kinetics (1977), Arch. Microbiol., 112, 247-254.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.3.13 2-Oxo-isohexanoate
-
Cupriavidus necator
2.3.3.13 CoA competitive against both 2-oxo-3-methylbutanoate and acetyl-CoA Cupriavidus necator
2.3.3.13 isopropylmalate competitive against both 2-oxo-3-methylbutanoate and acetyl-CoA Cupriavidus necator
2.3.3.13 leucine L-Leu Cupriavidus necator

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.3.3.13 0.06
-
2-oxo-3-methylbutanoate with acetyl-CoA as cosubstrate Cupriavidus necator
2.3.3.13 0.075
-
acetyl-CoA
-
Cupriavidus necator
2.3.3.13 0.1
-
propanoyl-CoA
-
Cupriavidus necator
2.3.3.13 0.4
-
butanoyl-CoA
-
Cupriavidus necator
2.3.3.13 0.4
-
2-oxo-n-pentanoate with acetyl-CoA as cosubstrate Cupriavidus necator
2.3.3.13 0.5
-
malonyl-CoA
-
Cupriavidus necator
2.3.3.13 0.9
-
pentanoyl-CoA
-
Cupriavidus necator
2.3.3.13 1.8
-
2-oxobutanoate with acetyl-CoA as cosubstrate Cupriavidus necator
2.3.3.13 5
-
2-oxo-3-methylbutanoyl-methylester with acetyl-CoA as cosubstrate Cupriavidus necator
2.3.3.13 10
-
pyruvate with acetyl-CoA as cosubstrate Cupriavidus necator

Organism

EC Number Organism UniProt Comment Textmining
2.3.3.13 Cupriavidus necator
-
-
-
2.3.3.13 Cupriavidus necator H 16
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.3.13 2-oxo-3-methylbutanoate + acetyl-CoA + H2O
-
Cupriavidus necator 3-hydroxy-4-methyl-3-carboxypentanoate + CoA
-
?
2.3.3.13 2-oxo-3-methylbutanoate + acetyl-CoA + H2O
-
Cupriavidus necator H 16 3-hydroxy-4-methyl-3-carboxypentanoate + CoA
-
?
2.3.3.13 2-oxo-3-methylbutanoate + butanoyl-CoA + H2O
-
Cupriavidus necator 3-ethyl-2-hydroxy-2-isopropylsuccinic acid + CoA
-
?
2.3.3.13 2-oxo-3-methylbutanoate + malonyl-CoA + H2O
-
Cupriavidus necator 2-hydroxy-3-metylbutane-11,2-tricarboxyl acid + CoA
-
?
2.3.3.13 2-oxo-3-methylbutanoate + propanoyl-CoA + H2O
-
Cupriavidus necator 2-hydroxy-2-isopropyl-3-methylsuccinic acid + CoA
-
?
2.3.3.13 2-oxo-3-methylbutanoate + propanoyl-CoA + H2O
-
Cupriavidus necator H 16 2-hydroxy-2-isopropyl-3-methylsuccinic acid + CoA
-
?
2.3.3.13 2-oxo-3-methylbutanoate + valeryl-CoA + H2O
-
Cupriavidus necator 2-hydroxy-2-isopropyl-3-propylsuccinic acid + CoA
-
?
2.3.3.13 2-oxo-3-methylbutanoyl-methylester + H2O
-
Cupriavidus necator 3-hydroxy-3-(methoxycarbonyl)-4-methylpentanoic acid + CoA
-
?
2.3.3.13 2-oxo-butanoate + acetyl-CoA + H2O
-
Cupriavidus necator 2-ethyl-2-hydroxysuccinic acid + CoA
-
?
2.3.3.13 2-oxo-butanoate + acetyl-CoA + H2O
-
Cupriavidus necator H 16 2-ethyl-2-hydroxysuccinic acid + CoA
-
?
2.3.3.13 2-oxo-n-pentanoate + acetyl-CoA + H2O
-
Cupriavidus necator 2-hydroxy-2-propylsuccinic acid + CoA
-
?
2.3.3.13 2-oxo-n-pentanoate + acetyl-CoA + H2O
-
Cupriavidus necator H 16 2-hydroxy-2-propylsuccinic acid + CoA
-
?
2.3.3.13 pyruvate + acetyl-CoA + H2O
-
Cupriavidus necator 2-hydroxy-2-methylsuccinic acid + CoA
-
?
2.3.3.13 pyruvate + acetyl-CoA + H2O
-
Cupriavidus necator H 16 2-hydroxy-2-methylsuccinic acid + CoA
-
?

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.3.3.13 0.5
-
isopropylmalate with respect to 2-oxo-3-methylbutanoate at a substrate concentration of 0.07 mM acetyl-CoA Cupriavidus necator
2.3.3.13 0.9
-
isopropylmalate with respect to acetyl-CoA at a substrate concentration of 0.375 mM 2-oxo-3-methylbutanoate Cupriavidus necator
2.3.3.13 4
-
isopropylmalate with respect to acetyl-CoA at a substrate concentration of 0.75 mM 2-oxo-3-methylbutanoate Cupriavidus necator