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Literature summary extracted from

  • Dupuy, C.; Ohayon, R.; Valent, A.; Noel-Hudson, M.S.; Deme, D.; Virion, A.
    Purification of a novel flavoprotein involved in the thyroid NADPH oxidase. Cloning of the porcine and human cDNAs (1999), J. Biol. Chem., 274, 37265-37269.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.6.3.1 cloning of full length cDNA Homo sapiens
1.6.3.1 cloning of full length cDNA Sus scrofa

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.6.3.1 apical plasma membrane
-
 Homo sapiens 16324
-
1.6.3.1 apical plasma membrane
-
 Sus scrofa 16324
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.6.3.1 Ca2+ required for full activity Homo sapiens
1.6.3.1 Ca2+ required for full activity Sus scrofa
1.6.3.1 Ca2+ regulates enzyme activity Homo sapiens
1.6.3.1 Ca2+ regulates enzyme activity Sus scrofa

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.6.3.1 138000
-
 calculated from cDNA sequence Homo sapiens
1.6.3.1 138000
-
 calculated from cDNA sequence Sus scrofa
1.6.3.1 180000
-
 SDS-PAGE, two minor bands at 150000 and 130000 Da Sus scrofa

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.6.3.1 NAD(P)H + H+ + O2 Caenorhabditis elegans
-
 NAD(P)+ + H2O2
-
 ?
1.6.3.1 NAD(P)H + H+ + O2 Homo sapiens production of hydrogen peroxide in thyroid gland that is required for thyroid hormone synthesis NAD(P)+ + H2O2
-
 ?
1.6.3.1 NAD(P)H + H+ + O2 Sus scrofa production of hydrogen peroxide in thyroid gland that is required for thyroid hormone synthesis NAD(P)+ + H2O2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.6.3.1 Caenorhabditis elegans O61213 high sequence similarities to mammalian proteins
-
1.6.3.1 Homo sapiens Q9NRD8
-
-
1.6.3.1 Sus scrofa Q8HZK2
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.6.3.1
-
 Sus scrofa

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.6.3.1 thyroid gland
-
 Homo sapiens
-
1.6.3.1 thyroid gland
-
 Sus scrofa
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.6.3.1 NAD(P)H + H+ + O2
-
 Homo sapiens NAD(P)+ + H2O2
-
 ?
1.6.3.1 NAD(P)H + H+ + O2
-
 Caenorhabditis elegans NAD(P)+ + H2O2
-
 ?
1.6.3.1 NAD(P)H + H+ + O2
-
 Sus scrofa NAD(P)+ + H2O2
-
 ?
1.6.3.1 NAD(P)H + H+ + O2 production of hydrogen peroxide in thyroid gland that is required for thyroid hormone synthesis Homo sapiens NAD(P)+ + H2O2
-
 ?
1.6.3.1 NAD(P)H + H+ + O2 production of hydrogen peroxide in thyroid gland that is required for thyroid hormone synthesis Sus scrofa NAD(P)+ + H2O2
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.6.3.1 FAD
-
 Homo sapiens
1.6.3.1 FAD flavoprotein Sus scrofa
1.6.3.1 NADPH binding site Homo sapiens
1.6.3.1 NADPH binding site Sus scrofa