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Literature summary extracted from

  • Murphy, C.D.; Schaffrath, C.; O'Hagan, D.
    Fluorinated natural products: the biosynthesis of fluoroacetate and 4-fluorothreonine in Streptomyces cattleya (2003), Chemosphere, 52, 455-461.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.2.1.69 fluroracetaldehyde + NAD+ + H2O Streptomyces cattleya
-
 fluoroacetate + NADH
-
 ?
1.2.1.69 fluroracetaldehyde + NAD+ + H2O Streptomyces cattleya NRRL 8057
-
 fluoroacetate + NADH
-
 ?
2.2.1.8 L-threonine + fluoroacetaldehyde Streptomyces cattleya enzyme is important in biosynthesis of 4-fluorothreonine acetaldehyde + 4-fluoro-L-threonine
-
 ?
2.2.1.8 L-threonine + fluoroacetaldehyde Streptomyces cattleya NRRL 8057 enzyme is important in biosynthesis of 4-fluorothreonine acetaldehyde + 4-fluoro-L-threonine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.69 Streptomyces cattleya
-
-
-
2.2.1.8 Streptomyces cattleya
-
 NRRL 8057
-
2.2.1.8 Streptomyces cattleya NRRL 8057
-
 NRRL 8057
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.69 fluroracetaldehyde + NAD+ + H2O
-
 Streptomyces cattleya fluoroacetate + NADH + H+
-
 ?
1.2.1.69 fluroracetaldehyde + NAD+ + H2O
-
 Streptomyces cattleya NRRL 8057 fluoroacetate + NADH + H+
-
 ?
1.2.1.69 fluroracetaldehyde + NAD+ + H2O
-
 Streptomyces cattleya fluoroacetate + NADH
-
 ?
1.2.1.69 fluroracetaldehyde + NAD+ + H2O
-
 Streptomyces cattleya NRRL 8057 fluoroacetate + NADH
-
 ?
2.2.1.8 L-threonine + chloroacetaldehyde
-
 Streptomyces cattleya acetaldehyde + 4-chloro-L-threonine
-
 ?
2.2.1.8 L-threonine + chloroacetaldehyde
-
 Streptomyces cattleya NRRL 8057 acetaldehyde + 4-chloro-L-threonine
-
 ?
2.2.1.8 L-threonine + fluoroacetaldehyde C3 and C4 of threonine are replaced with the aldehyde carbons, generating a new molecule of threonine Streptomyces cattleya acetaldehyde + 4-fluoro-L-threonine
-
 ?
2.2.1.8 L-threonine + fluoroacetaldehyde enzyme is important in biosynthesis of 4-fluorothreonine Streptomyces cattleya acetaldehyde + 4-fluoro-L-threonine
-
 ?
2.2.1.8 L-threonine + fluoroacetaldehyde C3 and C4 of threonine are replaced with the aldehyde carbons, generating a new molecule of threonine Streptomyces cattleya NRRL 8057 acetaldehyde + 4-fluoro-L-threonine
-
 ?
2.2.1.8 L-threonine + fluoroacetaldehyde enzyme is important in biosynthesis of 4-fluorothreonine Streptomyces cattleya NRRL 8057 acetaldehyde + 4-fluoro-L-threonine
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
2.2.1.8 pyridoxal 5'-phosphate pyridoxal 5'-phosphate protein Streptomyces cattleya