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Literature summary extracted from
- Mammalian monophenol monooxygenase (tyrosinase): purification, properties, and reactions catalyzed (1987), Methods Enzymol., 142, 154-165.
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.18.1 | L-3,4-dihydroxyphenylalanine + 1/2 O2 | Mammalia | - |
L-dopaquinone + H2O | - |
? |  |
| 1.14.18.1 | L-3,4-dihydroxyphenylalanine + 1/2 O2 | Mus musculus | - |
L-dopaquinone + H2O | - |
? | |
| 1.14.18.1 | L-tyrosine + O2 + AH2 | Mammalia | - |
L-3,4-dihydroxyphenylalanine + H2O + A | - |
? | |
| 1.14.18.1 | L-tyrosine + O2 + AH2 | Mus musculus | - |
L-3,4-dihydroxyphenylalanine + H2O + A | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.14.18.1 | Mammalia | - |
- |
- |
| 1.14.18.1 | Mus musculus | - |
B16 melanoma cells | - |
| 1.14.18.1 | Mus musculus | - |
isoenzymes T1, T2, T3 and T4 | - |
Posttranslational Modification
| EC Number | Posttranslational Modification | Comment | Organism |
|---|---|---|---|
| 1.14.18.1 | glycoprotein | - |
Mammalia |
| 1.14.18.1 | glycoprotein | - |
Mus musculus |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 1.14.18.1 | - |
Mammalia |
| 1.14.18.1 | ammonium sulfate, S-300 chromatography, preparative PAGE | Mus musculus |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.14.18.1 | melanoma cell | - |
Mammalia | - |
| 1.14.18.1 | melanoma cell | - |
Mus musculus | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 1.14.18.1 | additional information | - |
assay methods | Mammalia |
| 1.14.18.1 | 45 | - |
- |
Mammalia |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.18.1 | 4-methylcatechol + O2 | - |
Mammalia | 4-methyl-o-benzoquinone + H2O | - |
? | |
| 1.14.18.1 | 4-methylcatechol + O2 | - |
Mus musculus | 4-methyl-o-benzoquinone + H2O | - |
? | |
| 1.14.18.1 | L-3,4-dihydroxyphenylalanine + 1/2 O2 | - |
Mammalia | L-dopaquinone + H2O | - |
? | |
| 1.14.18.1 | L-3,4-dihydroxyphenylalanine + 1/2 O2 | - |
Mus musculus | L-dopaquinone + H2O | - |
? | |
| 1.14.18.1 | L-tyrosine + O2 + AH2 | - |
Mammalia | L-3,4-dihydroxyphenylalanine + H2O + A | - |
? | |
| 1.14.18.1 | L-tyrosine + O2 + AH2 | - |
Mus musculus | L-3,4-dihydroxyphenylalanine + H2O + A | - |
? | |
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