EC Number | General Stability | Organism |
---|---|---|
1.14.18.1 | highly resistant to SDS and proteinase K | Mus musculus |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.14.18.1 | 0.5 | - |
L-Dopa | - |
Mus musculus | |
1.14.18.1 | 0.5 | - |
L-Dopa | in B16/C3 tumor cell homogenates | Mus musculus |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
1.14.18.1 | 66000 | - |
x * 66000, isoenzyme 1, immunoblot | Mus musculus |
1.14.18.1 | 68000 | - |
x * 68000, isoenzyme 2, immunoblot | Mus musculus |
1.14.18.1 | 70000 | - |
x * 70000, isoenzyme 4, immunoblot | Mus musculus |
1.14.18.1 | 80000 | - |
x * 80000, isoenzyme 4, immunoblot | Mus musculus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.14.18.1 | L-3,4-dihydroxyphenylalanine + 1/2 O2 | Mus musculus | - |
L-dopaquinone + H2O | - |
? | |
1.14.18.1 | L-tyrosine + O2 + AH2 | Mus musculus | rate-limiting enzyme in melanin biosynthesis | L-3,4-dihydroxyphenylalanine + H2O + A | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.14.18.1 | Mus musculus | - |
B16 melanoma cells | - |
EC Number | Posttranslational Modification | Comment | Organism |
---|---|---|---|
1.14.18.1 | additional information | isoenzymes with molecular weights of 58000 Da and 68000 Da are highly resistant to proteinase K digestion | Mus musculus |
EC Number | Purification (Comment) | Organism |
---|---|---|
1.14.18.1 | proteinase K digest, DEAE-52 cellulose, 4 isozymes | Mus musculus |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.14.18.1 | melanoma cell | - |
Mus musculus | - |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
1.14.18.1 | 6889 | - |
- |
Mus musculus |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.14.18.1 | 4-methylcatechol + O2 | - |
Mus musculus | 4-methyl-o-benzoquinone + H2O | - |
? | |
1.14.18.1 | dopa + 1/2 O2 | L-dopa | Mus musculus | dopaquinone + H2O | - |
? | |
1.14.18.1 | L-3,4-dihydroxyphenylalanine + 1/2 O2 | - |
Mus musculus | L-dopaquinone + H2O | - |
? | |
1.14.18.1 | L-tyrosine + O2 + AH2 | rate-limiting enzyme in melanin biosynthesis | Mus musculus | L-3,4-dihydroxyphenylalanine + H2O + A | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
1.14.18.1 | ? | x * 80000, isoenzyme 4, immunoblot | Mus musculus |
1.14.18.1 | ? | x * 70000, isoenzyme 4, immunoblot | Mus musculus |
1.14.18.1 | ? | x * 66000, isoenzyme 1, immunoblot | Mus musculus |
1.14.18.1 | ? | x * 68000, isoenzyme 2, immunoblot | Mus musculus |