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Literature summary extracted from

  • Birney, E.C.; Jenness, R.; Hume, I.D.
    Ascorbic acid biosynthesis in the mammalian kidney (1979), Experientia, 35, 1425-1426.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.3.8 L-gulono-1,4-lactone + O2 Tachyglossus aculeatus
-
 L-xylo-hex-3-ulonolactone + H2O2
-
 ?
1.1.3.8 L-gulono-1,4-lactone + O2 Ornithorhynchus anatinus
-
 L-xylo-hex-3-ulonolactone + H2O2
-
 ?
1.1.3.8 L-gulono-1,4-lactone + O2 Perameles nasuta
-
 L-xylo-hex-3-ulonolactone + H2O2
-
 ?
1.1.3.8 L-gulono-1,4-lactone + O2 Isoodon macrourus
-
 L-xylo-hex-3-ulonolactone + H2O2
-
 ?
1.1.3.8 L-gulono-1,4-lactone + O2 Notamacropus rufogriseus
-
 L-xylo-hex-3-ulonolactone + H2O2
-
 ?
1.1.3.8 L-gulono-1,4-lactone + O2 Thylogale thetis
-
 L-xylo-hex-3-ulonolactone + H2O2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.3.8 Isoodon macrourus
-
 brindled bandicoot
-
1.1.3.8 Notamacropus rufogriseus
-
-
-
1.1.3.8 Ornithorhynchus anatinus
-
-
-
1.1.3.8 Perameles nasuta
-
 long-nosed bandicoot
-
1.1.3.8 Tachyglossus aculeatus
-
-
-
1.1.3.8 Thylogale thetis
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
1.1.3.8 L-gulono-1,4-lactone + O2 = L-xylo-hex-2-ulono-1,4-lactone + H2O2 product isomerizes spontaneously to L-ascorbate Tachyglossus aculeatus
a
1.1.3.8 L-gulono-1,4-lactone + O2 = L-xylo-hex-2-ulono-1,4-lactone + H2O2 product isomerizes spontaneously to L-ascorbate Ornithorhynchus anatinus
a
1.1.3.8 L-gulono-1,4-lactone + O2 = L-xylo-hex-2-ulono-1,4-lactone + H2O2 product isomerizes spontaneously to L-ascorbate Perameles nasuta
a
1.1.3.8 L-gulono-1,4-lactone + O2 = L-xylo-hex-2-ulono-1,4-lactone + H2O2 product isomerizes spontaneously to L-ascorbate Isoodon macrourus
a
1.1.3.8 L-gulono-1,4-lactone + O2 = L-xylo-hex-2-ulono-1,4-lactone + H2O2 product isomerizes spontaneously to L-ascorbate Notamacropus rufogriseus
a
1.1.3.8 L-gulono-1,4-lactone + O2 = L-xylo-hex-2-ulono-1,4-lactone + H2O2 product isomerizes spontaneously to L-ascorbate Thylogale thetis
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.3.8 kidney relatively high levels of gulonolactone oxidase in kidney and liver Perameles nasuta
-
1.1.3.8 kidney relatively high levels of gulonolactone oxidase in kidney and liver Isoodon macrourus
-
1.1.3.8 kidney primary locus of ascorbate is in liver Tachyglossus aculeatus
-
1.1.3.8 kidney primary locus of ascorbate is in liver Ornithorhynchus anatinus
-
1.1.3.8 liver relatively high levels of gulonolactone oxidase in kidney and liver Perameles nasuta
-
1.1.3.8 liver relatively high levels of gulonolactone oxidase in kidney and liver Isoodon macrourus
-
1.1.3.8 liver primary locus of ascorbate is in liver Notamacropus rufogriseus
-
1.1.3.8 liver primary locus of ascorbate is in liver Thylogale thetis
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.3.8 L-gulono-1,4-lactone + O2
-
 Tachyglossus aculeatus L-xylo-hex-3-ulonolactone + H2O2
-
 ?
1.1.3.8 L-gulono-1,4-lactone + O2
-
 Ornithorhynchus anatinus L-xylo-hex-3-ulonolactone + H2O2
-
 ?
1.1.3.8 L-gulono-1,4-lactone + O2
-
 Perameles nasuta L-xylo-hex-3-ulonolactone + H2O2
-
 ?
1.1.3.8 L-gulono-1,4-lactone + O2
-
 Isoodon macrourus L-xylo-hex-3-ulonolactone + H2O2
-
 ?
1.1.3.8 L-gulono-1,4-lactone + O2
-
 Notamacropus rufogriseus L-xylo-hex-3-ulonolactone + H2O2
-
 ?
1.1.3.8 L-gulono-1,4-lactone + O2
-
 Thylogale thetis L-xylo-hex-3-ulonolactone + H2O2
-
 ?
1.1.3.8 L-gulono-1,4-lactone + O2
-
 Tachyglossus aculeatus L-xylo-hex-3-ulonolactone + H2O2 product isomerizes spontaneously to L-ascorbate ?
1.1.3.8 L-gulono-1,4-lactone + O2
-
 Ornithorhynchus anatinus L-xylo-hex-3-ulonolactone + H2O2 product isomerizes spontaneously to L-ascorbate ?
1.1.3.8 L-gulono-1,4-lactone + O2
-
 Perameles nasuta L-xylo-hex-3-ulonolactone + H2O2 product isomerizes spontaneously to L-ascorbate ?
1.1.3.8 L-gulono-1,4-lactone + O2
-
 Isoodon macrourus L-xylo-hex-3-ulonolactone + H2O2 product isomerizes spontaneously to L-ascorbate ?
1.1.3.8 L-gulono-1,4-lactone + O2
-
 Notamacropus rufogriseus L-xylo-hex-3-ulonolactone + H2O2 product isomerizes spontaneously to L-ascorbate ?
1.1.3.8 L-gulono-1,4-lactone + O2
-
 Thylogale thetis L-xylo-hex-3-ulonolactone + H2O2 product isomerizes spontaneously to L-ascorbate ?