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Literature summary extracted from

  • Baldet, P.; Gerbling, H.; Axiotis, S.; Douce, R.
    Biotin biosynthesis in higher plant cells. Identification of intermediates (1993), Eur. J. Biochem., 217, 479-485.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.2.1.14 ATP + heptanedioate + CoA Lavandula vera first enzyme of biotin biosynthesis pathway ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.8.1.6 Lavandula vera
-
-
-
6.2.1.14 Lavandula vera
-
 biotin-overproducing cell line
-

Reaction

EC Number Reaction Comment Organism Reaction ID
2.8.1.6 dethiobiotin + sulfur-(sulfur carrier) + 2 S-adenosyl-L-methionine + 2 reduced [2Fe-2S] ferredoxin = biotin + (sulfur carrier) + 2 L-methionine + 2 5'-deoxyadenosine + 2 oxidized [2Fe-2S] ferredoxin the reaction proceeds in two distinct steps involving mercaptodethiobiotin as an intermediate Lavandula vera
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.8.1.6 cell culture
-
 Lavandula vera
-
6.2.1.14 cell culture
-
 Lavandula vera
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.8.1.6 dethiobiotin + sulfur intermediate is 9-mercaptodethiobiotin Lavandula vera biotin
-
 ?
6.2.1.14 ATP + heptanedioate + CoA
-
 Lavandula vera AMP + diphosphate + heptanedioyl-CoA
-
 ?
6.2.1.14 ATP + heptanedioate + CoA first enzyme of biotin biosynthesis pathway Lavandula vera ?
-
 ?