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Literature summary extracted from

  • Gulzar, M.S.; Akhtar, M.; Gani, D.
    Preparation of N-substituted aspartic acids via enantiospecific conjugate addition of N-nucleophiles to fumaric acids using methylaspartase: synthetic utility and mechanistic implications (1997), J. Chem. Soc. Perkin Trans. I, 1197, 649-655.
No PubMed abstract available

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.3.1.2 L-threo-3-methylaspartate Escherichia coli
-
 ?
-
 ?
4.3.1.2 additional information Escherichia coli ammonia is the natural nucleophile for the enzyme ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.3.1.2 Escherichia coli
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
4.3.1.2 L-threo-3-methylaspartate = mesaconate + NH3 stereochemical mechanism Escherichia coli
a

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.3.1.2 (2S)-2-hydrazinosuccinic acid
-
 Escherichia coli fumarate + hydrazine
-
 ?
4.3.1.2 (2S)-N,N-dimethylaspartic acid
-
 Escherichia coli fumarate + dimethylamine
-
 ?
4.3.1.2 (2S)-N-ethylaspartic acid
-
 Escherichia coli fumarate + ethylamine
-
 ?
4.3.1.2 (2S)-N-hydroxyaspartic acid
-
 Escherichia coli fumarate + hydroxylamine
-
 ?
4.3.1.2 (2S)-N-methoxyaspartic acid
-
 Escherichia coli fumarate + methoxylamine
-
 ?
4.3.1.2 (2S)-N-methylaspartic acid
-
 Escherichia coli fumarate + methylamine
-
 ?
4.3.1.2 (2S,3S)-N-hydroxy-3-ethylaspartic acid
-
 Escherichia coli ethylfumarate + hydroxylamine
-
 ?
4.3.1.2 (2S,3S)-N-hydroxy-3-methylaspartic acid
-
 Escherichia coli mesaconate + hydroxylamine
-
 ?
4.3.1.2 (2S,3S)-N-methoxy-3-methylaspartic acid
-
 Escherichia coli mesaconate + methoxylamine
-
 ?
4.3.1.2 2-hydrazino-3-chlorosuccinic acid
-
 Escherichia coli chlorofumarate + hydrazine
-
 ?
4.3.1.2 2-hydrazino-3-ethylsuccinic acid
-
 Escherichia coli ethylfumarate + hydrazine
-
 ?
4.3.1.2 2-hydrazino-3-isopropylsuccinic acid
-
 Escherichia coli isopropylfumarate + hydrazine
-
 ?
4.3.1.2 2-hydrazino-3-propylsuccinic acid
-
 Escherichia coli propylfumarate + hydrazine
-
 ?
4.3.1.2 erythro-3-methylaspartate (2S,3R)-3-methylaspartic acid Escherichia coli ?
-
 ?
4.3.1.2 hydrazino-3-methylsuccinic acid
-
 Escherichia coli mesaconate + hydrazine
-
 ?
4.3.1.2 L-threo-3-methylaspartate r Escherichia coli mesaconate + NH3
-
 ?
4.3.1.2 L-threo-3-methylaspartate (2S,3S)-3-methylaspartic acid Escherichia coli mesaconate + NH3
-
 ?
4.3.1.2 L-threo-3-methylaspartate
-
 Escherichia coli ?
-
 ?
4.3.1.2 additional information
-
 Escherichia coli ?
-
 ?
4.3.1.2 additional information ammonia is the natural nucleophile for the enzyme Escherichia coli ?
-
 ?
4.3.1.2 N,3-dimethylaspartic acid
-
 Escherichia coli methylfumarate + methylamine
-
 ?
4.3.1.2 N-methyl-3-ethylaspartic acid
-
 Escherichia coli ethylfumarate + methylamine
-
 ?