Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Vanhaesebroeck, B.; Welham, M.J.; Kotani, K.; Stein, R.; Warne, P.H.; Zvelebil, M.J.; Higashi, K.; Volinia, S.; Downward, J.; Waterfield, M.D.
    P110delta, a novel phosphoinositide 3-kinase in leukocytes (1997), Proc. Natl. Acad. Sci. USA, 94, 4330-4335.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.1.137
-
 Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.153 LY294002
-
 Homo sapiens
2.7.1.153 Wortmannin
-
 Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.7.1.153 119471
-
 x * 119471, p110delta subunit, can bind the p85 adaptor subunit, calculation from nucleotide sequence Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.137 Homo sapiens O00329
-
-
2.7.1.153 Homo sapiens O00329
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.137 leukocyte p110delta is exclusively found in leukocytes Homo sapiens
-
2.7.1.153 leukocyte p110delta is exclusively localized in leukocytes Homo sapiens
-
2.7.1.153 MCF-7 cell
-
 Homo sapiens
-
2.7.1.153 MOLT-4 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.137 ATP + 1-phosphatidylinositol
-
 Homo sapiens ADP + phosphatidylinositol 3-phosphate
-
 ?
2.7.1.153 ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
 Homo sapiens ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
-
 ?
2.7.1.153 ATP + phosphatidylinositol
-
 Homo sapiens ADP + phosphatidylinositol 3-phosphate
-
 ?
2.7.1.153 ATP + phosphatidylinositol 4-phosphate
-
 Homo sapiens ADP + phosphatidylinositol 4,5-diphosphate
-
 ?
2.7.1.153 additional information p110delta does not phosphorylate the p85 adaptor but instead harbors an intrinsic autophosphorylation capacity Homo sapiens ?
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.1.153 ? x * 119471, p110delta subunit, can bind the p85 adaptor subunit, calculation from nucleotide sequence Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
2.7.1.137 p110delta I PI3K.
-
 Homo sapiens