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Literature summary extracted from

  • Wang, X.L.; Akhtar, R.A.; Abdel-Latif, A.A.
    Studies on the properties of myo-inositol-1,4,5-trisphosphate 5-phosphatase and myo-inositol monophosphatase in bovine iris sphincter smooth muscle: effects of okadaic acid and protein phosphorylation (1994), Biochim. Biophys. Acta, 1222, 27-36.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.3.25 ATP
-
 Bos taurus
3.1.3.25 Ca2+
-
 Bos taurus
3.1.3.25 Disulfiram
-
 Bos taurus
3.1.3.25 Li+
-
 Bos taurus
3.1.3.56 ATP
-
 Bos taurus
3.1.3.56 Ca2+ above 0.001 mM Bos taurus
3.1.3.56 Disulfiram
-
 Bos taurus
3.1.3.56 EDTA
-
 Bos taurus
3.1.3.56 thimerosal
-
 Bos taurus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.3.25 0.89
-
 DL-myo-inositol 1-phosphate
-
 Bos taurus
3.1.3.56 0.029
-
 D-myo-inositol 1,4,5-trisphosphate pH 7.4, 37°C Bos taurus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.3.56 microsome
-
 Bos taurus
-
-
3.1.3.56 soluble
-
 Bos taurus
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.1.3.25 Mg2+
-
 Bos taurus
3.1.3.56 Ca2+ moderate inhibition Bos taurus
3.1.3.56 Mg2+
-
 Bos taurus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.3.56 D-myo-inositol 1,4,5-trisphosphate + H2O Bos taurus regulation of intracellular Ca2+ level by degradation of intracellular Ca2+ releasing second messenger D-myo-inositol 1,4,5-trisphosphate D-myo-inositol 1,4-bisphosphate + phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.25 Bos taurus
-
-
-
3.1.3.56 Bos taurus
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.1.3.56 additional information protein kinase A and C do not influence activity Bos taurus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.3.25 iris sphincter muscle
-
 Bos taurus
-
3.1.3.56 muscle iris spincter smooth muscle Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.25 DL-myo-inositol 1-phosphate + H2O
-
 Bos taurus DL-myo-inositol + phosphate
-
 ?
3.1.3.56 D-myo-inositol 1,4,5-trisphosphate + H2O
-
 Bos taurus D-myo-inositol 1,4-bisphosphate + phosphate
-
 ?
3.1.3.56 D-myo-inositol 1,4,5-trisphosphate + H2O regulation of intracellular Ca2+ level by degradation of intracellular Ca2+ releasing second messenger D-myo-inositol 1,4,5-trisphosphate Bos taurus D-myo-inositol 1,4-bisphosphate + phosphate
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.3.25 7
-
-
 Bos taurus
3.1.3.56 8
-
-
 Bos taurus

pH Range

EC Number pH Minimum pH Maximum Comment Organism
3.1.3.56 6 9
-
 Bos taurus