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Literature summary extracted from

  • Londesborough, J.C.; Webster, L.T.
    Fatty acyl-CoA synthetases (1974), The Enzymes, 3rd Ed. (Boyer, P. D. , ed. ), 10, 469-488.
No PubMed abstract available

Activating Compound

EC Number Activating Compound Comment Organism Structure
6.2.1.1 acetate required for ATP-diphosphate exchange Bos taurus

General Stability

EC Number General Stability Organism
6.2.1.1 photoinactivation in presence of methylene blue Oryctolagus cuniculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.2.1.1 seleno-CoA competitive to CoA Bos taurus
6.2.1.10 F- 2 mM, complete inhibition Rattus norvegicus
6.2.1.10 phosphate 5 mM, 70% inhibition Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
6.2.1.1 0.017
-
ATP in Tris buffer, pH 6.7, 200 mM K+ Bos taurus
6.2.1.1 0.1
-
ATP in Pipes buffer, pH 6.7, 200 mM K+ Bos taurus
6.2.1.1 0.14
-
acetate pH 6.7, 200 mM K+ Bos taurus
6.2.1.1 0.21
-
CoA
-
Bos taurus
6.2.1.1 0.22
-
acetate CoA, in Tris buffer, pH 8.3, 200 mM K+ Bos taurus
6.2.1.1 0.28
-
CoA in Tris buffer, pH 6.7, 200 mM K+ Bos taurus
6.2.1.1 0.35
-
ATP Tris buffer, pH 8.3, 200 mM K+ Bos taurus
6.2.1.1 0.65
-
acetate
-
Bos taurus
6.2.1.1 0.71
-
ATP
-
Bos taurus
6.2.1.1 1.2
-
CoA in Pipes buffer, pH 6.7, 200 mM K+ Bos taurus
6.2.1.10 0.2
-
Octanoate
-
Rattus norvegicus
6.2.1.10 0.22
-
Butyrate
-
Rattus norvegicus
6.2.1.10 2.1
-
oleate
-
Rattus norvegicus
6.2.1.10 3.3
-
CoA
-
Rattus norvegicus
6.2.1.10 3.3
-
palmitate
-
Rattus norvegicus
6.2.1.10 4.3
-
GTP
-
Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
6.2.1.10 mitochondrion
-
Rattus norvegicus 5739
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
6.2.1.1 Ca2+ two types of divalent metal ion requirement, 1. Mg2+, Mn2+, Fe2+, Co2+ or Ca2+ required for the formation of the enzyme-bound acetyl adenylate, 2. Ni2+, Cd2+, Fe2+ or Cu2+ required for adenylate binding Bos taurus
6.2.1.1 Cd2+ two types of divalent metal ion requirement, 1. Mg2+, Mn2+, Fe2+, Co2+ or Ca2+ required for the formation of the enzyme-bound acetyl adenylate, 2. Ni2+, Cd2+, Fe2+ or Cu2+ required for adenylate binding Bos taurus
6.2.1.1 Co2+ two types of divalent metal ion requirement, 1. Mg2+, Mn2+, Fe2+, Co2+ or Ca2+ required for the formation of the enzyme-bound acetyl adenylate, 2. Ni2+, Cd2+, Fe2+ or Cu2+ required for adenylate binding Bos taurus
6.2.1.1 Cu2+ two types of divalent metal ion requirement, 1. Mg2+, Mn2+, Fe2+, Co2+ or Ca2+ required for the formation of the enzyme-bound acetyl adenylate, 2. Ni2+, Cd2+, Fe2+ or Cu2+ required for adenylate binding Bos taurus
6.2.1.1 Fe2+ two types of divalent metal ion requirement, 1. Mg2+, Mn2+, Fe2+, Co2+ or Ca2+ required for the formation of the enzyme-bound acetyl adenylate, 2. Ni2+, Cd2+, Fe2+ or Cu2+ required for adenylate binding Bos taurus
6.2.1.1 K+ activates, absolute requirement for certain monovalent cations, no inhibition at high concentrations Bos taurus
6.2.1.1 Li+ activation at 5-8 mM, absolute requirement for certain monovalent cations, inhibition above 10 mM Bos taurus
6.2.1.1 Mg2+ required Bos taurus
6.2.1.1 Mg2+ two types of divalent metal ion requirement, 1. Mg2+, Mn2+, Fe2+, Co2+ or Ca2+ required for the formation of the enzyme-bound acetyl adenylate, 2. Ni2+, Cd2+, Fe2+ or Cu2+ required for adenylate binding Bos taurus
6.2.1.1 Mn2+ two types of divalent metal ion requirement, 1. Mg2+, Mn2+, Fe2+, Co2+ or Ca2+ required for the formation of the enzyme-bound acetyl adenylate, 2. Ni2+, Cd2+, Fe2+ or Cu2+ required for adenylate binding Bos taurus
6.2.1.1 Na+ activation at 5-8 mM, absolute requirement for certain monovalent cations, inhibition above 10 mM Bos taurus
6.2.1.1 NH4+ activates, absolute requirement for certain monovalent cations, no inhibition at high concentrations Bos taurus
6.2.1.1 Ni2+ two types of divalent metal ion requirement, 1. Mg2+, Mn2+, Fe2+, Co2+ or Ca2+ required for the formation of the enzyme-bound acetyl adenylate, 2. Ni2+, Cd2+, Fe2+ or Cu2+ required for adenylate binding Bos taurus
6.2.1.1 Rb+ activates, absolute requirement for certain monovalent cations, no inhibition at high concentrations Bos taurus
6.2.1.1 Tris activates, absolute requirement for certain monovalent cations, no inhibition at high concentrations Bos taurus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
6.2.1.10 20000
-
gel filtration Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
6.2.1.1 Aspergillus niger
-
-
-
6.2.1.1 Bos taurus
-
-
-
6.2.1.1 Euglena gracilis
-
-
-
6.2.1.1 Oryctolagus cuniculus
-
-
-
6.2.1.1 Rattus norvegicus
-
-
-
6.2.1.10 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.2.1.1 adipose tissue
-
Rattus norvegicus
-
6.2.1.1 brain
-
Rattus norvegicus
-
6.2.1.1 brain
-
Bos taurus
-
6.2.1.1 heart
-
Rattus norvegicus
-
6.2.1.1 heart
-
Bos taurus
-
6.2.1.1 liver
-
Rattus norvegicus
-
6.2.1.1 liver
-
Oryctolagus cuniculus
-
6.2.1.10 liver
-
Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.2.1.1 ATP + acetate + CoA
-
Rattus norvegicus AMP + diphosphate + acetyl-CoA
-
?
6.2.1.1 ATP + acetate + CoA
-
Oryctolagus cuniculus AMP + diphosphate + acetyl-CoA
-
?
6.2.1.1 ATP + acetate + CoA
-
Euglena gracilis AMP + diphosphate + acetyl-CoA
-
?
6.2.1.1 ATP + acetate + CoA
-
Aspergillus niger AMP + diphosphate + acetyl-CoA
-
?
6.2.1.1 ATP + acetate + CoA neither glutathione nor pantetheine can substitute for CoA as acyl acceptor Bos taurus AMP + diphosphate + acetyl-CoA
-
?
6.2.1.1 ATP + acetate + seleno-CoA
-
Bos taurus AMP + diphosphate + acetyl-seleno-CoA
-
?
6.2.1.1 ATP + acrylate + CoA
-
Bos taurus AMP + diphosphate + acryloyl-CoA
-
?
6.2.1.1 ATP + butyrate + CoA isobutyrate Bos taurus AMP + diphosphate + butyryl-CoA
-
?
6.2.1.1 ATP + fluoroacetate + CoA
-
Bos taurus AMP + diphosphate + fluoroacetyl-CoA
-
?
6.2.1.1 ATP + propanoate + CoA
-
Bos taurus AMP + diphosphate + propanoyl-CoA
-
?
6.2.1.1 dATP + acetate + CoA 70% of the activity relative to ATP Bos taurus dAMP + diphosphate + acetyl-CoA
-
?
6.2.1.1 additional information
-
Oryctolagus cuniculus ?
-
?
6.2.1.1 additional information enzyme catalyzes acetate-dependent ATP-diphosphate exchange Bos taurus ?
-
?
6.2.1.10 GTP + butyrate + CoA
-
Rattus norvegicus GDP + phosphate + butyryl-CoA
-
?
6.2.1.10 GTP + octanoate + CoA
-
Rattus norvegicus GDP + phosphate + octanoyl-CoA
-
?
6.2.1.10 GTP + oleate + CoA
-
Rattus norvegicus GDP + phosphate + oleoyl-CoA
-
?
6.2.1.10 GTP + palmitate + CoA
-
Rattus norvegicus GDP + phosphate + palmitoyl-CoA
-
?
6.2.1.10 additional information the different specificity of the isolated GTP-dependent enzymes for fatty acid substrates results from their different lecithin contents Rattus norvegicus ?
-
?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
6.2.1.1 8
-
ATP-diphosphate exchange Bos taurus

Cofactor

EC Number Cofactor Comment Organism Structure
6.2.1.10 4'-phosphopantetheine contains 1 M 4ยด-phosphopantetheine per 20000 g enzyme Rattus norvegicus