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Literature summary extracted from

  • Bachovchin, W.W.; Eagar Jr., R.G.; Moore, K.W.; Richards, J.H.
    Mechanism of action of Adenosylcobalamin: glycerol and other substrate analogues as substrates and inactivators for propanediol dehydratase - kinetics, stereospecificity, and mechanism (1977), Biochemistry, 16, 1082-1092.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.2.1.28 glycerol stereospecificity: enzyme-R-glycerol complex responsible for product-formation, enzyme-S-glycerol complex responsible for inactivation, several molecules of glycerol per enzyme molecule involved, active-site inhibition, C3-methyl group plays crucial role; suicide inactivation in vitro, reactivation possible in presence of coenzyme, Mg2+, ATP in vivo Klebsiella pneumoniae
4.2.1.28 additional information substrate analogues Klebsiella pneumoniae

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
4.2.1.28 additional information
-
additional information
-
Klebsiella pneumoniae
4.2.1.28 0.186
-
(S)-1,2-Propanediol
-
Klebsiella pneumoniae
4.2.1.28 0.3
-
RS-1,2-propanediol
-
Klebsiella pneumoniae
4.2.1.28 0.6
-
(R)-1,2-Propanediol
-
Klebsiella pneumoniae
4.2.1.28 16
-
glycerol
-
Klebsiella pneumoniae

Organism

EC Number Organism UniProt Comment Textmining
4.2.1.28 Klebsiella pneumoniae
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.2.1.28 (R)-1,2-propanediol
-
Klebsiella pneumoniae propanal + H2O
-
?
4.2.1.28 (S)-1,2-propanediol
-
Klebsiella pneumoniae propanal + H2O
-
?
4.2.1.28 1,2-propanediol
-
Klebsiella pneumoniae propanal
-
?
4.2.1.28 glycerol
-
Klebsiella pneumoniae beta-hydroxypropionaldehyde
-
?

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
4.2.1.28 additional information
-
additional information glycerol analogues Klebsiella pneumoniae
4.2.1.28 317
-
glycerol
-
Klebsiella pneumoniae

Cofactor

EC Number Cofactor Comment Organism Structure
4.2.1.28 cobamide mechanism of coenzyme action Klebsiella pneumoniae