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Literature summary extracted from

  • Braunstein, A.E.; Goryachenkova, E.V.; Tolosa, E.A.; Willhardt, I.H.; Yefremova, L.L.
    Specificity and some other properties of liver serine sulphhydrolase: evidence for its identity with cystathionine beta-synthase (1971), Biochim. Biophys. Acta, 242, 247-260.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.2.1.22 hydroxylamine
-
 Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
4.2.1.22 18
-
 homocysteine cosubstrate L-Ser Rattus norvegicus
4.2.1.22 24
-
 2-mercaptoethanol cosubstrate L-Cys Rattus norvegicus
4.2.1.22 36
-
 L-Cys cosubstrate 2-mercaptoethanol Rattus norvegicus
4.2.1.22 68
-
 DL-homocysteine cosubstrate L-Ser Rattus norvegicus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
4.2.1.22 250000
-
 fresh enzyme extract, gel filtration Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.2.1.22 L-Serine + homocysteine Gallus gallus synthesis of cystathionine ?
-
 ?
4.2.1.22 L-Serine + homocysteine Rattus norvegicus synthesis of cystathionine ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.2.1.22 Gallus gallus
-
-
-
4.2.1.22 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.2.1.22 liver
-
 Gallus gallus
-
4.2.1.22 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.2.1.22 beta-Chloro-DL-alanine + DL-homocysteine
-
 Rattus norvegicus ?
-
 ?
4.2.1.22 beta-Cyano-DL-alanine + DL-homocysteine
-
 Rattus norvegicus ?
-
 ?
4.2.1.22 DL-Serine-O-sulfate + DL-homocysteine
-
 Rattus norvegicus ?
-
 ?
4.2.1.22 L-Cysteine + 2-mercaptoethanol
-
 Rattus norvegicus HOOC-CH(NH2)-CH2-S-CH2-CH2OH + H2S
-
 ?
4.2.1.22 L-Serine + homocysteine
-
 Gallus gallus Cystathionine + H2O
-
 ?
4.2.1.22 L-Serine + homocysteine
-
 Rattus norvegicus Cystathionine + H2O
-
 ?
4.2.1.22 L-Serine + homocysteine synthesis of cystathionine Gallus gallus ?
-
 ?
4.2.1.22 L-Serine + homocysteine synthesis of cystathionine Rattus norvegicus ?
-
 ?
4.2.1.22 S-Methyl-L-cysteine + DL-homocysteine
-
 Rattus norvegicus ?
-
 ?