Literature summary extracted from

Ames, B.N.
The biosynthesis of histidine: D-erythro-imidazole-glycerol phosphate dehydrase (1957), J. Biol. Chem., 228, 131-143.

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
4.2.1.19	EDTA	-	Neurospora crassa

KM Value [mM]

EC Number	KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
4.2.1.19	0.24	-	D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate	-	Neurospora crassa

Metals/Ions

EC Number	Metals/Ions	Comment	Organism	Structure
4.2.1.19	additional information	not activated by Mg2+, Ni2+, Cd2+, Fe2+, Co2+	Neurospora crassa

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
4.2.1.19	D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate	Neurospora crassa	-	?	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
4.2.1.19	Neurospora crassa	-	-	-

Purification (Commentary)

EC Number	Purification (Comment)	Organism
4.2.1.19	-	Neurospora crassa

Specific Activity [micromol/min/mg]

EC Number	Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
4.2.1.19	0.195	-	-	Neurospora crassa

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
4.2.1.19	D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate	-	Neurospora crassa	3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O	-	?
4.2.1.19	D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate	-	Neurospora crassa	?	-	?

pH Optimum

EC Number	pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
4.2.1.19	7.5	-	-	Neurospora crassa

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Release 2023.1 (January 2023)