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Literature summary extracted from
- Subunit structure and photooxidation of yeast imidazoleglycerolphosphate dehydratase (1974), Biochemistry, 13, 5145-5152.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.2.1.19 | 2-mercaptoethanol | activation | Saccharomyces cerevisiae |  |
| 4.2.1.19 | cysteine | activation | Saccharomyces cerevisiae | |
| 4.2.1.19 | mercaptoethylamine | activation | Saccharomyces cerevisiae | |
General Stability
| EC Number | General Stability | Organism |
|---|---|---|
| 4.2.1.19 | Mg2+, Mn2+, glycerol, dithiothreitol do not stablilize | Saccharomyces cerevisiae |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.2.1.19 | 3-Amino-1,2,4-triazole | - |
Saccharomyces cerevisiae | |
| 4.2.1.19 | additional information | not inhibited by histidinol phosphate, histidinol, histidine | Saccharomyces cerevisiae |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 4.2.1.19 | 0.54 | - |
D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate | - |
Saccharomyces cerevisiae | |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.2.1.19 | Mn2+ | Km: 0.0076 mM | Saccharomyces cerevisiae | |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 4.2.1.19 | 35000 | - |
x * 35000, SDS-PAGE | Saccharomyces cerevisiae |
| 4.2.1.19 | 290000 | - |
gel filtration | Saccharomyces cerevisiae |
| 4.2.1.19 | 300000 | - |
gel electrophoresis | Saccharomyces cerevisiae |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 4.2.1.19 | Saccharomyces cerevisiae | - |
- |
- |
Oxidation Stability
| EC Number | Oxidation Stability | Organism |
|---|---|---|
| 4.2.1.19 | photooxidation in presence of Rose Bengal | Saccharomyces cerevisiae |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 4.2.1.19 | - |
Saccharomyces cerevisiae |
Reaction
| EC Number | Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|---|
| 4.2.1.19 | D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O | energy of activation 15900 cal/mol | Saccharomyces cerevisiae |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 4.2.1.19 | 0.31 | - |
- |
Saccharomyces cerevisiae |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.2.1.19 | D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate | - |
Saccharomyces cerevisiae | 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 4.2.1.19 | polymer | x * 35000, SDS-PAGE | Saccharomyces cerevisiae |
Temperature Stability [°C]
| EC Number | Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 4.2.1.19 | 54 | - |
60 min stable | Saccharomyces cerevisiae |
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Release 2023.1 (January 2023)
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