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Literature summary extracted from

  • Messner, B.; Eggerer, H.; Cornforth, J.W.; Mallaby, R.
    Substrate stereochemistry of the hydroxymethylglutaryl-CoA lyase and methylglutaconyl-CoA hydratase reactions (1975), Eur. J. Biochem., 53, 255-264.
No PubMed abstract available

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.1.3.4 (S)-3-Hydroxy-3-methylglutaryl-CoA Bos taurus leucine catabolism ?
-
 ?
4.2.1.18 (S)-3-Hydroxy-3-methylglutaryl-CoA Ovis aries enzyme is involved in Leu degradation ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.1.3.4 Bos taurus
-
 bovine
-
4.2.1.18 Ovis aries
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
4.1.3.4 (S)-3-Hydroxy-3-methylglutaryl-CoA = acetyl-CoA + acetoacetate enzyme is stereospecific and proceeds with inversion of configuration Bos taurus
a
4.2.1.18 (S)-3-hydroxy-3-methylglutaryl-CoA = trans-3-methylglutaconyl-CoA + H2O syn-addition-elimination of H2O Ovis aries
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.1.3.4 liver
-
 Bos taurus
-
4.2.1.18 liver
-
 Ovis aries
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
4.1.3.4 1.3
-
-
 Bos taurus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.3.4 (S)-3-Hydroxy-3-methylglutaryl-CoA leucine catabolism Bos taurus ?
-
 ?
4.2.1.18 (S)-3-hydroxy-3-methylglutaryl-CoA
-
 Ovis aries trans-3-methylglutaconyl-CoA + H2O
-
 ?
4.2.1.18 (S)-3-Hydroxy-3-methylglutaryl-CoA enzyme is involved in Leu degradation Ovis aries ?
-
 ?