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Literature summary extracted from

  • Pu, R.T.; Osmani, S.A.
    Mitotic destruction of the cell cycle regulated NIMA protein kinase of Aspergillus nidulans is required for mitotic exit (1995), EMBO J., 14, 995-1003.
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
2.7.11.22 additional information partial C-terminal deletion of NIMA generates a highly toxic kinase although the kinase domain alone is not toxic Aspergillus nidulans

General Stability

EC Number General Stability Organism
2.7.11.22 partially truncated NIMA is far more stable than the full length NIMA protein which likely accounts for its toxicity Aspergillus nidulans

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.22 ATP + protein Aspergillus nidulans NIMA is a cell cycle regulated protein kinase required, in addition to p34cdc2/cyclin B, for initiation of mitosis. NIMA accumulates when cells are arrested in G2 and is degraded as cells traverse mitosis. NIMA degradation during mitosis is required for correct mitotic progression in Aspergillus nidulans ADP + phosphoprotein
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 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.22 Aspergillus nidulans P11837
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.22 mitotic cell NIMA accumulates when cells are arrested in G2 and is degraded as cells traverse mitosis Aspergillus nidulans
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2.7.11.22 additional information NIMA accumulates when cells are arrested in G2 and is degraded as cells traverse mitosis Aspergillus nidulans
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.22 ATP + protein NIMA is a cell cycle regulated protein kinase required, in addition to p34cdc2/cyclin B, for initiation of mitosis. NIMA accumulates when cells are arrested in G2 and is degraded as cells traverse mitosis. NIMA degradation during mitosis is required for correct mitotic progression in Aspergillus nidulans Aspergillus nidulans ADP + phosphoprotein
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 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.22 G2-specific protein kinase NIMA
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 Aspergillus nidulans
2.7.11.22 NIMA protein kinase
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 Aspergillus nidulans