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Literature summary extracted from

  • Zhang, W.; Inouye, M.; Inouye, S.
    Reciprocal regulation of the differentiation of Myxococcus xanthus by Pkn5 and Pkn6, eukaryotic-like Ser/Thr protein kinases (1996), Mol. Microbiol., 20, 435-447.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.11.1 expression in Escherichia coli Myxococcus xanthus
2.7.11.1 Pkn6-PhoA fusion protein expressed in Escherichia coli Myxococcus xanthus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.11.1 cytoplasm
-
 Myxococcus xanthus 5737
-
2.7.11.1 membrane the Pkn6-PhoA fusion protein in Escherichia coli has a single transmembrane domain with the N-terminal domain in the cytoplasm and the C-terminal domain outside the cytoplasmic membrane Myxococcus xanthus 16020
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.1 ATP + a protein Myxococcus xanthus Pkn5 negatively regulates Myxococcus xanthus development ADP + a phosphoprotein
-
 ?
2.7.11.1 ATP + a protein Myxococcus xanthus expressed constitutively throughout the life cycle, with slight increases at an early stage of development ADP + a phosphoprotein
-
 ?
2.7.11.1 ATP + a protein Myxococcus xanthus Pkn6 may be a transmembrane sensor of external signals for development ADP + a phosphoprotein
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.1 Myxococcus xanthus P54737
-
-
2.7.11.1 Myxococcus xanthus P54738
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.7.11.1 phosphoprotein autophosphorylation only at Ser Myxococcus xanthus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.1 ATP + a protein Pkn5 is autophosphorylated only at Ser Myxococcus xanthus ADP + a phosphoprotein
-
 ?
2.7.11.1 ATP + a protein Pkn6 is autophosphorylated both at Ser and Thr Myxococcus xanthus ADP + a phosphoprotein
-
 ?
2.7.11.1 ATP + a protein Pkn5 negatively regulates Myxococcus xanthus development Myxococcus xanthus ADP + a phosphoprotein
-
 ?
2.7.11.1 ATP + a protein expressed constitutively throughout the life cycle, with slight increases at an early stage of development Myxococcus xanthus ADP + a phosphoprotein
-
 ?
2.7.11.1 ATP + a protein Pkn6 may be a transmembrane sensor of external signals for development Myxococcus xanthus ADP + a phosphoprotein
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.1 serine/threonine-protein kinase pkn5
-
 Myxococcus xanthus
2.7.11.1 serine/threonine-protein kinase pkn6
-
 Myxococcus xanthus