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Literature summary extracted from

  • Peirs, P.; De Wit, L.; Braibant, M.; Huygen, K.; Content, J.
    A serine/threonine protein kinase from Mycobacterium tuberculosis (1997), Eur. J. Biochem., 244, 604-612.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.11.1 expression in Escherichia coli Mycobacterium tuberculosis

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.1 staurosporine inhibits phosphorylation of myelin basic proteins Mycobacterium tuberculosis

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.11.1 membrane deduced amino acid sequence contains two transmembrane segments, which flank a highly repetitive region, suggesting a receptor-like anchoring Mycobacterium tuberculosis 16020
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.1 Mn2+ required Mycobacterium tuberculosis

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.7.11.1 70000
-
 x * 70000 Mycobacterium tuberculosis

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.1 Mycobacterium tuberculosis P9WI79
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.7.11.1 phosphoprotein autophosphorylation on Thr Mycobacterium tuberculosis

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.11.1 recombinant enzyme is purified as a fusion protein with gluthatione S-transferase Mycobacterium tuberculosis

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.1 ATP + a protein autophosphorylation on Thr Mycobacterium tuberculosis ADP + a phosphoprotein
-
 ?
2.7.11.1 ATP + histone histones from calf thymus, phosphorylation on Ser Mycobacterium tuberculosis ADP + phosphorylated histone
-
 ?
2.7.11.1 ATP + myelin basic protein myelin basic proteins from bovine brain, phosphorylation on Ser Mycobacterium tuberculosis ADP + phosphorylated myelin basic protein
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.11.1 ? x * 70000 Mycobacterium tuberculosis

Synonyms

EC Number Synonyms Comment Organism
2.7.11.1 serine/threonine-protein kinase pknD
-
 Mycobacterium tuberculosis