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Literature summary extracted from

  • Becker, W.; Weber, Y.; Wetzel, K.; Eirmbter, K.; Tejedor, F.J.; Joost, H.G.
    Sequence characteristics, subcellular localization, and substrate specificity of DYRK-related kinases, a novel family of dual specificity protein kinases (1998), J. Biol. Chem., 273, 25893-25902.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.12.1 fusion protein of DYRK1A accumulates in the nucleus of transfected COS-7 and HEK293 cells, expression in Escherichia coli Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.12.1 additional information nuclear localization of DYRK1A is mediated by its nuclear targeting signal, amino acids 105-139, but ist characteristic subnuclear distribution depends on additional N-terminal elements, amino acids 1-104 Homo sapiens
-
-

Organism

EC Number Organism UniProt Comment Textmining
2.7.12.1 Homo sapiens O43781
-
-
2.7.12.1 Homo sapiens Q92630
-
-
2.7.12.1 Rattus norvegicus Q63470
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.7.12.1 phosphoprotein autophosphorylation Rattus norvegicus
2.7.12.1 phosphoprotein autophosphorylation Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.12.1 testis
-
 Homo sapiens
-
2.7.12.1 testis predominately expressed in testis Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.12.1 ATP + protein autophosphorylation Rattus norvegicus ADP + phosphoprotein
-
 ?
2.7.12.1 ATP + protein autophosphorylation Homo sapiens ADP + phosphoprotein
-
 ?
2.7.12.1 ATP + protein when expressed in E. coli the enzyme catalyzes autophosphorylation on Tyr residues Rattus norvegicus ADP + phosphoprotein
-
 ?
2.7.12.1 ATP + protein when expressed in E. coli the enzyme catalyzes autophosphorylation on Tyr residues Homo sapiens ADP + phosphoprotein
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.12.1 dual-specificity tyrosine-phosphorylation regulated kinase 1A
-
 Rattus norvegicus
2.7.12.1 dual-specificity tyrosine-phosphorylation regulated kinase 2
-
 Homo sapiens
2.7.12.1 dual-specificity tyrosine-phosphorylation regulated kinase 3
-
 Homo sapiens
2.7.12.1 DYRK1A
-
 Rattus norvegicus