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Literature summary extracted from

  • Hennig, M.; D'Arcy, A.; Hampele, I.C.; Page, M.G.P.; Oefner, C.; Dale, G.E.
    Crystal structure and reaction mechanism of 7,8-dihydroneopterin aldolase from Staphylococcus aureus (1998), Nat. Struct. Biol., 5, 357-362.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.1.2.25
-
 Staphylococcus aureus

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
4.1.2.25
-
 Staphylococcus aureus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
4.1.2.25 13751
-
 8 * 13751, calculation from nucleotide sequence Staphylococcus aureus
4.1.2.25 110000
-
 sedimentation equilibrium centrifugation Staphylococcus aureus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.1.2.25 2-Amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine Staphylococcus aureus the enzyme is involved in the de novo synthesis of folic acid from guanosine triphosphate ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.1.2.25 Staphylococcus aureus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
4.1.2.25
-
 Staphylococcus aureus

Reaction

EC Number Reaction Comment Organism Reaction ID
4.1.2.25 7,8-dihydroneopterin = 6-(hydroxymethyl)-7,8-dihydropterin + glycolaldehyde mechanism Staphylococcus aureus
a

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.2.25 2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine
-
 Staphylococcus aureus 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + glycolaldehyde
-
 ?
4.1.2.25 2-Amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine the enzyme is involved in the de novo synthesis of folic acid from guanosine triphosphate Staphylococcus aureus ?
-
 ?

Subunits

EC Number Subunits Comment Organism
4.1.2.25 More four molecules assemble into a ring, and two rings come together to give a cylinder with a hole of at least 13 A diameter Staphylococcus aureus
4.1.2.25 octamer 8 * 13751, calculation from nucleotide sequence Staphylococcus aureus