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Literature summary extracted from
- Properties of fructose-1,6-bisphosphate aldolase from Escherichia coli: an NMR analysis (1995), Arch. Biochem. Biophys., 317, 244-252.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.1.2.13 | 3-phosphoglycerate | - |
Escherichia coli |  |
| 4.1.2.13 | diphosphate | - |
Escherichia coli | |
| 4.1.2.13 | EDTA | - |
Escherichia coli | |
| 4.1.2.13 | glyceraldehyde 3-phosphate | - |
Escherichia coli | |
| 4.1.2.13 | glycerone phosphate | - |
Escherichia coli | |
| 4.1.2.13 | Polyphosphate | - |
Escherichia coli | |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.1.2.13 | Cd2+ | can partially restore activity of metal depleted enzyme | Escherichia coli | |
| 4.1.2.13 | Mn2+ | can partially restore activity of metal depleted enzyme | Escherichia coli | |
| 4.1.2.13 | Zn2+ | the function appears to be the polarization of the C=O bound of glycerone phosphate. Each subunit of the dimer binds one Zn2+ | Escherichia coli | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 4.1.2.13 | Escherichia coli | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 4.1.2.13 | - |
Escherichia coli |
Reaction
| EC Number | Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|---|
| 4.1.2.13 | D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate | the enzyme binds and utilizes only the carbonyl forms of fructose 1,6-diphosphate and glycerone phosphate | Escherichia coli |
Storage Stability
| EC Number | Storage Stability | Organism |
|---|---|---|
| 4.1.2.13 | -10°C, stable for up to 12 months | Escherichia coli |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.1.2.13 | D-fructose 1,6-bisphosphate | - |
Escherichia coli | glycerone phosphate + D-glyceraldehyde 3-phosphate | - |
? | |
| 4.1.2.13 | D-Fructose 1-phosphate | at 3.5% of the activity with fructose 1,6-diphosphate | Escherichia coli | Glycerone phosphate + D-glyceraldehyde | - |
? | |
Temperature Stability [°C]
| EC Number | Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 4.1.2.13 | 25 | - |
3 d, 25% loss of activity | Escherichia coli |
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