EC Number | Application | Comment | Organism |
---|---|---|---|
4.2.3.17 | medicine | chemotherapeutic agent against a range of cancers, including ovarian and breast cancer | Taxus brevifolia |
EC Number | Cloned (Comment) | Organism |
---|---|---|
4.2.3.17 | overexpression in Escherichia coli | Taxus brevifolia |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
4.2.3.17 | 0.003 | - |
geranylgeranyl diphosphate | native enzyme | Taxus brevifolia | |
4.2.3.17 | 0.0031 | - |
geranylgeranyl diphosphate | thioredoxin fusion | Taxus brevifolia | |
4.2.3.17 | 0.0105 | - |
geranylgeranyl diphosphate | M1 preprotein | Taxus brevifolia | |
4.2.3.17 | 0.014 | - |
geranylgeranyl diphosphate | M93 | Taxus brevifolia | |
4.2.3.17 | 0.0159 | - |
geranylgeranyl diphosphate | M79 | Taxus brevifolia |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
4.2.3.17 | geranylgeranyl diphosphate | Taxus brevifolia | catalyzes the first step in taxol biosynthesis | taxa-4,11-diene + diphosphate | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
4.2.3.17 | Taxus brevifolia | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
4.2.3.17 | - |
Taxus brevifolia |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
4.2.3.17 | cyclopropylidene | - |
Taxus brevifolia | ? | - |
? | |
4.2.3.17 | geranylgeranyl diphosphate | - |
Taxus brevifolia | taxa-4(5),11(12)-diene + diphosphate | - |
? | |
4.2.3.17 | geranylgeranyl diphosphate | taxa-4(20),11(12)-diene is formed as a small amount | Taxus brevifolia | taxa-4(20),11(12)-diene + diphosphate | - |
? | |
4.2.3.17 | geranylgeranyl diphosphate | catalyzes the first step in taxol biosynthesis | Taxus brevifolia | taxa-4,11-diene + diphosphate | - |
? |
EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
4.2.3.17 | 0.00004 | - |
geranylgeranyl diphosphate | M1 preprotein | Taxus brevifolia | |
4.2.3.17 | 0.0000417 | - |
geranylgeranyl diphosphate | thioredoxin fusion | Taxus brevifolia | |
4.2.3.17 | 0.000133 | - |
geranylgeranyl diphosphate | M93 | Taxus brevifolia | |
4.2.3.17 | 0.00017 | - |
geranylgeranyl diphosphate | M79 | Taxus brevifolia | |
4.2.3.17 | 0.000177 | - |
geranylgeranyl diphosphate | native enzyme | Taxus brevifolia |