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Literature summary extracted from

  • Paudel, H.K.; Xu, Y.H.; Jarrett, H.W.; Carlson, G.M.
    The model calmodulin-binding peptide melittin inhibits phosphorylase kinase by interacting with its catalytic center (1993), Biochemistry, 32, 11865-11872.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.19 Melittin model calmodulin-binding peptide, mechanism, kinetic, phosphorylase b as substrate Oryctolagus cuniculus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.11.19 0.0098
-
 Melittin
-
 Oryctolagus cuniculus
2.7.11.19 0.0276
-
 phosphorylase b holoenzyme Oryctolagus cuniculus
2.7.11.19 0.07
-
 MgATP2- ATP (+ melittin) Oryctolagus cuniculus
2.7.11.19 0.08
-
 MgATP2- ATP (+ tetrapeptide) Oryctolagus cuniculus
2.7.11.19 0.0824
-
 phosphorylase b gamma subunit Oryctolagus cuniculus
2.7.11.19 0.3085
-
 tetradecapeptide
-
 Oryctolagus cuniculus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.19 Mg2+ requirement Oryctolagus cuniculus
2.7.11.19 Mg2+ major role of Mg2+: cosubstrate in Mg2+-ATP complex Oryctolagus cuniculus
2.7.11.19 phosphate requirement, phosphate containing enzyme Oryctolagus cuniculus

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.19 Oryctolagus cuniculus
-
 new Zealand white
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.19 ATP + melittin
-
 Oryctolagus cuniculus ADP + phosphomelittin
-
 ?
2.7.11.19 ATP + phosphorylase b cosubstrate: Mg-ATP complex Oryctolagus cuniculus ADP + phosphorylase a
-
 ?
2.7.11.19 ATP + tetradecapeptide
-
 Oryctolagus cuniculus ADP + phosphorylated tetradecapeptide
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.11.19 30
-
 assay at Oryctolagus cuniculus

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
2.7.11.19 0.0983
-
 Melittin
-
 Oryctolagus cuniculus
2.7.11.19 23.6
-
 tetradecapeptide
-
 Oryctolagus cuniculus
2.7.11.19 57.1
-
 phosphorylase b
-
 Oryctolagus cuniculus