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Literature summary extracted from

  • Picton, C.; Shenolikar, S.; Grand, R.; Cohen, P.
    Calmodulin as an integral subunit of phosphorylase kinase from rabbit skeletal muscle (1983), Methods Enzymol., 102, 219-227.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.19 Troponin i.e. complex of troponin C, I and T, activation, as effective as troponin C, forms complex with beta subunit Oryctolagus cuniculus
2.7.11.19 troponin C activation Oryctolagus cuniculus
2.7.11.19 troponin C can replace extrinsic calmodulin Oryctolagus cuniculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.19 Calcineurin i.e. calmodulin-binding protein, blocks activation by calmodulin Oryctolagus cuniculus
2.7.11.19 Trifluoperazine prevents activation by troponin C Oryctolagus cuniculus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.19 Ca2+
-
 Oryctolagus cuniculus
2.7.11.19 Mg2+ requirement Oryctolagus cuniculus
2.7.11.19 Mg2+ major role of Mg2+: cosubstrate in Mg2+-ATP complex Oryctolagus cuniculus
2.7.11.19 phosphate requirement, phosphate containing enzyme Oryctolagus cuniculus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.7.11.19 17000
-
 4 * 145000 + 4 * 130000 + 4 * 45000 + 4 * 17000, (alphabetagammadelta)4, rabbit, SDS-PAGE Oryctolagus cuniculus
2.7.11.19 45000
-
 4 * 145000 + 4 * 130000 + 4 * 45000 + 4 * 17000, (alphabetagammadelta)4, rabbit, SDS-PAGE Oryctolagus cuniculus
2.7.11.19 130000
-
 4 * 145000 + 4 * 130000 + 4 * 45000 + 4 * 17000, (alphabetagammadelta)4, rabbit, SDS-PAGE Oryctolagus cuniculus
2.7.11.19 145000
-
 4 * 145000 + 4 * 130000 + 4 * 45000 + 4 * 17000, (alphabetagammadelta)4, rabbit, SDS-PAGE Oryctolagus cuniculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.19 ATP + glycogen phosphorylase Oryctolagus cuniculus conversion to an AMP-independent form, key enzyme of neural and hormonal control of glycogen metabolism ?
-
 ?
2.7.11.19 ATP + glycogen synthase Oryctolagus cuniculus key enzyme of neural and hormonal control of glycogen metabolism ?
-
 ?
2.7.11.19 ATP + glycogen synthase Oryctolagus cuniculus conversion to a glucose 6-phosphate dependent form ?
-
 ?
2.7.11.19 ATP + phosphorylase b Oryctolagus cuniculus i.e. EC 2.4.1.1 or glycogen phosphorylase ?
-
 ?
2.7.11.19 ATP + phosphorylase b Oryctolagus cuniculus key enzyme of neural and hormonal control of glycogen metabolism ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.19 Oryctolagus cuniculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.19 skeletal muscle
-
 Oryctolagus cuniculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.19 ATP + glycogen phosphorylase conversion to an AMP-independent form, key enzyme of neural and hormonal control of glycogen metabolism Oryctolagus cuniculus ?
-
 ?
2.7.11.19 ATP + glycogen synthase key enzyme of neural and hormonal control of glycogen metabolism Oryctolagus cuniculus ?
-
 ?
2.7.11.19 ATP + glycogen synthase conversion to a glucose 6-phosphate dependent form Oryctolagus cuniculus ?
-
 ?
2.7.11.19 ATP + glycogen synthase phosphorylatable residue: Ser-7 Oryctolagus cuniculus ADP + phosphoglycogen synthase
-
 ?
2.7.11.19 ATP + phosphorylase b i.e. EC 2.4.1.1 or glycogen phosphorylase Oryctolagus cuniculus ADP + phosphorylase a
-
 ?
2.7.11.19 ATP + phosphorylase b cosubstrate: Mg-ATP complex Oryctolagus cuniculus ADP + phosphorylase a
-
 ?
2.7.11.19 ATP + phosphorylase b phosphorylation site located 14 residues from amino terminal Oryctolagus cuniculus ADP + phosphorylase a
-
 ?
2.7.11.19 ATP + phosphorylase b i.e. EC 2.4.1.1 or glycogen phosphorylase Oryctolagus cuniculus ?
-
 ?
2.7.11.19 ATP + phosphorylase b key enzyme of neural and hormonal control of glycogen metabolism Oryctolagus cuniculus ?
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.11.19 hexadecamer 4 * 145000 + 4 * 130000 + 4 * 45000 + 4 * 17000, (alphabetagammadelta)4, rabbit, SDS-PAGE Oryctolagus cuniculus

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.19 Calmodulin requirement Oryctolagus cuniculus
2.7.11.19 Calmodulin calmodulin containing enzyme i.e. tightly bound delta subunit Oryctolagus cuniculus
2.7.11.19 Calmodulin calmodulin containing enzyme in the absence of Ca2+ Oryctolagus cuniculus
2.7.11.19 Calmodulin tightly bound molecule interacts with additional calmodulin in the presence of Ca2+ Oryctolagus cuniculus