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Literature summary extracted from

  • Carlson, G.M.; Bechtel, P.J.; Graves, D.J.
    Chemical and regulatory properties of phosphorylase kinase and cyclic AMP-dependent protein kinase (1979), Adv. Enzymol. Relat. Areas Mol. Biol., 50, 41-115.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.19 Catalytic subunit of cAMP-dependent protein kinase activation of nonactivated enzyme Mus musculus
2.7.11.19 Catalytic subunit of cAMP-dependent protein kinase activation of nonactivated enzyme Oryctolagus cuniculus
2.7.11.19 Catalytic subunit of cAMP-dependent protein kinase activation of nonactivated enzyme Calliphoridae
2.7.11.19 Catalytic subunit of cAMP-dependent protein kinase activation of nonactivated enzyme Squalus acanthias
2.7.11.19 glycogen activation Mus musculus
2.7.11.19 glycogen activation Oryctolagus cuniculus
2.7.11.19 glycogen activation Calliphoridae
2.7.11.19 glycogen activation Squalus acanthias
2.7.11.19 heparin activation Mus musculus
2.7.11.19 heparin activation Oryctolagus cuniculus
2.7.11.19 heparin activation Calliphoridae
2.7.11.19 heparin activation Squalus acanthias
2.7.11.19 heparin pH-dependent Mus musculus
2.7.11.19 heparin pH-dependent Oryctolagus cuniculus
2.7.11.19 heparin pH-dependent Calliphoridae
2.7.11.19 heparin pH-dependent Squalus acanthias
2.7.11.19 additional information autophosphorylation Mus musculus
2.7.11.19 additional information autophosphorylation Oryctolagus cuniculus
2.7.11.19 additional information autophosphorylation Calliphoridae
2.7.11.19 additional information autophosphorylation Squalus acanthias
2.7.11.19 additional information phosphorylation by protein kinases Mus musculus
2.7.11.19 additional information phosphorylation by protein kinases Oryctolagus cuniculus
2.7.11.19 additional information phosphorylation by protein kinases Calliphoridae
2.7.11.19 additional information phosphorylation by protein kinases Squalus acanthias
2.7.11.19 additional information the nonactivated enzyme is activated either by limited proteolysis Mus musculus
2.7.11.19 additional information the nonactivated enzyme is activated either by limited proteolysis Oryctolagus cuniculus
2.7.11.19 additional information the nonactivated enzyme is activated either by limited proteolysis Calliphoridae
2.7.11.19 additional information the nonactivated enzyme is activated either by limited proteolysis Squalus acanthias
2.7.11.19 Proteases
-
 Mus musculus
2.7.11.19 Proteases
-
 Oryctolagus cuniculus
2.7.11.19 Proteases
-
 Calliphoridae
2.7.11.19 Proteases
-
 Squalus acanthias
2.7.11.19 Trypsin proteolytic activation of nonactivated enzyme Mus musculus
2.7.11.19 Trypsin proteolytic activation of nonactivated enzyme Oryctolagus cuniculus
2.7.11.19 Trypsin proteolytic activation of nonactivated enzyme Calliphoridae
2.7.11.19 Trypsin proteolytic activation of nonactivated enzyme Squalus acanthias
2.7.11.19 Trypsin strong, by limited proteolysis of alpha and beta subunits (not gamma) Mus musculus
2.7.11.19 Trypsin strong, by limited proteolysis of alpha and beta subunits (not gamma) Oryctolagus cuniculus
2.7.11.19 Trypsin strong, by limited proteolysis of alpha and beta subunits (not gamma) Calliphoridae
2.7.11.19 Trypsin strong, by limited proteolysis of alpha and beta subunits (not gamma) Squalus acanthias
2.7.11.19 Trypsin strong, by limited proteolysis of alpha and beta subunits Mus musculus
2.7.11.19 Trypsin strong, by limited proteolysis of alpha and beta subunits Oryctolagus cuniculus
2.7.11.19 Trypsin strong, by limited proteolysis of alpha and beta subunits Calliphoridae
2.7.11.19 Trypsin strong, by limited proteolysis of alpha and beta subunits Squalus acanthias

General Stability

EC Number General Stability Organism
2.7.11.19 Rabbit muscle enzyme is subject to pressure denaturation leading to the formation of polydisperse aggregates Oryctolagus cuniculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.19 DTNB
-
 Calliphoridae
2.7.11.19 DTNB
-
 Mus musculus
2.7.11.19 DTNB
-
 Oryctolagus cuniculus
2.7.11.19 DTNB
-
 Squalus acanthias
2.7.11.19 glucose 6-phosphate
-
 Calliphoridae
2.7.11.19 glucose 6-phosphate
-
 Mus musculus
2.7.11.19 glucose 6-phosphate
-
 Oryctolagus cuniculus
2.7.11.19 glucose 6-phosphate
-
 Squalus acanthias
2.7.11.19 KCl
-
 Calliphoridae
2.7.11.19 KCl
-
 Mus musculus
2.7.11.19 KCl
-
 Squalus acanthias
2.7.11.19 additional information no inhibition by glucose 1-phosphate (gammadelta subunit complex); no inhibition by UDPglucose Calliphoridae
2.7.11.19 additional information no inhibition by glucose 1-phosphate (gammadelta subunit complex); no inhibition by UDPglucose Mus musculus
2.7.11.19 additional information no inhibition by glucose 1-phosphate (gammadelta subunit complex); no inhibition by UDPglucose Oryctolagus cuniculus
2.7.11.19 additional information no inhibition by glucose 1-phosphate (gammadelta subunit complex); no inhibition by UDPglucose Squalus acanthias
2.7.11.19 Polyaspartic acid pH 8.2 Calliphoridae
2.7.11.19 Polyaspartic acid pH 8.2 Mus musculus
2.7.11.19 Polyaspartic acid pH 8.2 Oryctolagus cuniculus
2.7.11.19 Polyaspartic acid pH 8.2 Squalus acanthias
2.7.11.19 protamine pH 8.2 Calliphoridae
2.7.11.19 protamine pH 8.2 Mus musculus
2.7.11.19 protamine pH 8.2 Oryctolagus cuniculus
2.7.11.19 protamine pH 8.2 Squalus acanthias

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.11.19 additional information
-
 additional information pH-dependence of kinetic parameters Mus musculus
2.7.11.19 additional information
-
 additional information pH-dependence of kinetic parameters Oryctolagus cuniculus
2.7.11.19 additional information
-
 additional information pH-dependence of kinetic parameters Calliphoridae
2.7.11.19 additional information
-
 additional information pH-dependence of kinetic parameters Squalus acanthias
2.7.11.19 additional information
-
 additional information kinetic properties, overview Mus musculus
2.7.11.19 additional information
-
 additional information kinetic properties, overview Oryctolagus cuniculus
2.7.11.19 additional information
-
 additional information kinetic properties, overview Calliphoridae
2.7.11.19 additional information
-
 additional information kinetic properties, overview Squalus acanthias
2.7.11.19 additional information
-
 additional information kinetic data for phosphorylase b Mus musculus
2.7.11.19 additional information
-
 additional information kinetic data for phosphorylase b Oryctolagus cuniculus
2.7.11.19 additional information
-
 additional information kinetic data for phosphorylase b Calliphoridae
2.7.11.19 additional information
-
 additional information kinetic data for phosphorylase b Squalus acanthias

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.11.19 sarcoplasmic reticulum
-
 Mus musculus 16529
-
2.7.11.19 sarcoplasmic reticulum
-
 Oryctolagus cuniculus 16529
-
2.7.11.19 sarcoplasmic reticulum
-
 Calliphoridae 16529
-
2.7.11.19 sarcoplasmic reticulum
-
 Squalus acanthias 16529
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.19 Ca2+
-
 Oryctolagus cuniculus
2.7.11.19 Ca2+ requirement Mus musculus
2.7.11.19 Ca2+ requirement Calliphoridae
2.7.11.19 Ca2+ requirement Squalus acanthias
2.7.11.19 Li+ activation Mus musculus
2.7.11.19 Li+ activation Oryctolagus cuniculus
2.7.11.19 Li+ activation Calliphoridae
2.7.11.19 Li+ activation Squalus acanthias
2.7.11.19 Li+ LiBr Mus musculus
2.7.11.19 Li+ LiBr Oryctolagus cuniculus
2.7.11.19 Li+ LiBr Calliphoridae
2.7.11.19 Li+ LiBr Squalus acanthias
2.7.11.19 Mg2+ requirement Mus musculus
2.7.11.19 Mg2+ requirement Oryctolagus cuniculus
2.7.11.19 Mg2+ requirement Calliphoridae
2.7.11.19 Mg2+ requirement Squalus acanthias
2.7.11.19 Mg2+ major role of Mg2+: cosubstrate in Mg2+-ATP complex Mus musculus
2.7.11.19 Mg2+ major role of Mg2+: cosubstrate in Mg2+-ATP complex Oryctolagus cuniculus
2.7.11.19 Mg2+ major role of Mg2+: cosubstrate in Mg2+-ATP complex Calliphoridae
2.7.11.19 Mg2+ major role of Mg2+: cosubstrate in Mg2+-ATP complex Squalus acanthias
2.7.11.19 phosphate requirement, phosphate containing enzyme Mus musculus
2.7.11.19 phosphate requirement, phosphate containing enzyme Oryctolagus cuniculus
2.7.11.19 phosphate requirement, phosphate containing enzyme Calliphoridae
2.7.11.19 phosphate requirement, phosphate containing enzyme Squalus acanthias

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.7.11.19 additional information
-
 amino acid composition Mus musculus
2.7.11.19 additional information
-
 amino acid composition Oryctolagus cuniculus
2.7.11.19 additional information
-
 amino acid composition Calliphoridae
2.7.11.19 additional information
-
 amino acid composition Squalus acanthias
2.7.11.19 1330000
-
 analytical ultracentrifugation Oryctolagus cuniculus

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.19 Calliphoridae
-
 blowfly
-
2.7.11.19 Mus musculus
-
-
-
2.7.11.19 Oryctolagus cuniculus
-
-
-
2.7.11.19 Squalus acanthias
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.11.19 overview Oryctolagus cuniculus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.19 cardiac muscle
-
 Oryctolagus cuniculus
-
2.7.11.19 cardiac muscle
-
 Squalus acanthias
-
2.7.11.19 flight muscle
-
 Calliphoridae
-
2.7.11.19 liver
-
 Oryctolagus cuniculus
-
2.7.11.19 liver
-
 Squalus acanthias
-
2.7.11.19 additional information isozyme distribution in different tissues Mus musculus
-
2.7.11.19 additional information isozyme distribution in different tissues Oryctolagus cuniculus
-
2.7.11.19 additional information isozyme distribution in different tissues Calliphoridae
-
2.7.11.19 additional information isozyme distribution in different tissues Squalus acanthias
-
2.7.11.19 skeletal muscle
-
 Mus musculus
-
2.7.11.19 skeletal muscle
-
 Oryctolagus cuniculus
-
2.7.11.19 skeletal muscle
-
 Squalus acanthias
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.19 ATP + myosin light chain kinase rabbit Oryctolagus cuniculus ?
-
 ?
2.7.11.19 ATP + phosphorylase b cosubstrate: Mg-ATP complex Mus musculus ADP + phosphorylase a
-
 ?
2.7.11.19 ATP + phosphorylase b cosubstrate: Mg-ATP complex Oryctolagus cuniculus ADP + phosphorylase a
-
 ?
2.7.11.19 ATP + phosphorylase b cosubstrate: Mg-ATP complex Calliphoridae ADP + phosphorylase a
-
 ?
2.7.11.19 ATP + phosphorylase b cosubstrate: Mg-ATP complex Squalus acanthias ADP + phosphorylase a
-
 ?
2.7.11.19 ATP + synthetic peptides derived from phosphorylase b overview Mus musculus ?
-
 ?
2.7.11.19 ATP + synthetic peptides derived from phosphorylase b overview Oryctolagus cuniculus ?
-
 ?
2.7.11.19 ATP + synthetic peptides derived from phosphorylase b overview Calliphoridae ?
-
 ?
2.7.11.19 ATP + synthetic peptides derived from phosphorylase b overview Squalus acanthias ?
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.11.19 More spatial arrangement of subunits Mus musculus
2.7.11.19 More spatial arrangement of subunits Oryctolagus cuniculus
2.7.11.19 More spatial arrangement of subunits Squalus acanthias

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.11.19 additional information
-
-
 Mus musculus
2.7.11.19 additional information
-
-
 Calliphoridae
2.7.11.19 additional information
-
-
 Squalus acanthias
2.7.11.19 additional information
-
 pI: 5.77 (nonactivated rabbit enzyme) Oryctolagus cuniculus