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Literature summary extracted from

  • Pages, G.; Brunet, A.; L'Allemain, G.; Pouyssegur, J.
    Constitutive mutant and putative regulatory serine phosphorylation site of mammalian MAP kinase kinase (MEK1) (1994), EMBO J., 13, 3003-3010.
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
2.7.12.2 D208N mutation abolishes MAPKK activity Cricetulus griseus
2.7.12.2 S222A mutation abolishes MAPKK activity, shows a reduction in phosphorylation in response to active MAPKKK and exerts a dominant negative effect on the serum-stimulated endogenous MAPKK Cricetulus griseus

Organism

EC Number Organism UniProt Comment Textmining
2.7.12.2 Cricetulus griseus Q63980
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Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.7.12.2 phosphoprotein Ser222 represents one key MAPKKK-dependent phosphorylation site switching on and off the activity of MAPKK, an event crucial for growth control Cricetulus griseus

Synonyms

EC Number Synonyms Comment Organism
2.7.12.2 dual specificity mitogen-activated protein kinase kinase 1
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 Cricetulus griseus
2.7.12.2 mammalian MAP kinase kinase
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 Cricetulus griseus
2.7.12.2 MEK1
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 Cricetulus griseus