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Literature summary extracted from

  • Blank, J.L.; Gerwins, P.; Elliott, E.M.; Sather, S.; Johnson, G.L.
    Molecular cloning of mitogen-activated protein/ERK kinase kinases (MEKK) 2 and 3. Regulation of sequential phosphorylation pathways involving mitogen-activated protein kinase and c-Jun kinase (1996), J. Biol. Chem., 271, 5361-5368.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.12.2 expression in HEK293 cells Mus musculus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.7.12.2 69200
-
 x * 69200 Mus musculus
2.7.12.2 71000
-
 x * 71000 Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.12.2 ATP + protein Mus musculus MEKK 2 preferentially activates JNK ADP + phosphoprotein
-
 ?
2.7.12.2 ATP + protein Mus musculus MEKK 3 preferentially activates p42/44MAPK ADP + phosphoprotein
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.12.2 Mus musculus Q61083
-
-
2.7.12.2 Mus musculus Q61084
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.12.2 ATP + protein MEKK 2 preferentially activates JNK Mus musculus ADP + phosphoprotein
-
 ?
2.7.12.2 ATP + protein MEKK 3 preferentially activates p42/44MAPK Mus musculus ADP + phosphoprotein
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.12.2 ? x * 71000 Mus musculus
2.7.12.2 ? x * 69200 Mus musculus

Synonyms

EC Number Synonyms Comment Organism
2.7.12.2 MEKK 2
-
 Mus musculus
2.7.12.2 mitogen-activated protein kinase kinase kinase 2
-
 Mus musculus
2.7.12.2 mitogen-activated protein kinase kinase kinase 3
-
 Mus musculus
2.7.12.2 mitogen-activated protein/ERK kinase kinase
-
 Mus musculus