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Literature summary extracted from

  • Kosako, H.; Nishida, E.; Gotoh, Y.
    cDNA cloning of MAP kinase kinase reveals kinase cascade pathways in yeasts to vertebrates (1993), EMBO J., 12, 787-794.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.12.2 bacterial expression Xenopus laevis

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.7.12.2 45000
-
 x * 45000 Xenopus laevis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.12.2 ATP + protein Xenopus laevis the enzyme functions as a direct upstream activator for a presumed MAP kinase homolog in each signal transduction pathway involved in the regulation of cell cycle progression or cellular responses to extracellular signals ADP + phosphoprotein
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.12.2 Xenopus laevis Q05116
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.12.2 ATP + MAP kinase
-
 Xenopus laevis ADP + phosphorylated MAP kinase
-
 ?
2.7.12.2 ATP + protein the enzyme undergoes autophosphorylation on Ser, Thr and Tyr Xenopus laevis ADP + phosphoprotein
-
 ?
2.7.12.2 ATP + protein the enzyme functions as a direct upstream activator for a presumed MAP kinase homolog in each signal transduction pathway involved in the regulation of cell cycle progression or cellular responses to extracellular signals Xenopus laevis ADP + phosphoprotein
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.12.2 ? x * 45000 Xenopus laevis

Synonyms

EC Number Synonyms Comment Organism
2.7.12.2 dual specificity mitogen-activated protein kinase kinase 1
-
 Xenopus laevis